Abstract

The aim of this project is to elucidate the neuronal (CNS) mechanisms that mediate the effects of several hallucinogens (psychotomimetics) and other, related compounds. To this end, a sensitive, specific, robust and reliable """"""""behavioral asset"""""""" in which rats or pigeons are trained to detect (discriminate) drug-induced alterations in their own internal environments (states), will be used to study several clinically-important ergot alkaloids including lergotrile and dihydro-ergotoxine (Hydergine). These compounds have been used to treat a variety of cardiovascular, neuroendocrine and neuropsychiatric disorders ranging from migraine headache to Parkinsonism and senile dementia. Special attention will be paid to (1) the extent to which the discriminable effects of therapeutic ergots resemble those of their close structural congener lysergic acid diethylamide (LSD) and therefore might predict hallucinogenic or psychotominetic liability; (2) the neuronal mechanisms underlying ergot cues; (3) possible correlations between the discriminable and (other) physiological and neurochemical effects of ergots.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA002543-12
Application #
3207406
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1980-04-01
Project End
1986-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of South Carolina at Columbia
Department
Type
Schools of Arts and Sciences
DUNS #
111310249
City
Columbia
State
SC
Country
United States
Zip Code
29208

  Publications

Appel, James B; West, William B; Buggy, James (2004) LSD, 5-HT (serotonin), and the evolution of a behavioral assay. Neurosci Biobehav Rev 27:693-701
Appel, J B; West, W B; Rolandi, W G et al. (1999) Increasing the selectivity of drug discrimination procedures. Pharmacol Biochem Behav 64:353-8
Van Groll, B J; Appel, J B (1992) Stimulus effects of d-amphetamine 1: DA mechanisms. Pharmacol Biochem Behav 43:967-73
Callahan, P M; Appel, J B; Cunningham, K A (1991) Dopamine D1 and D2 mediation of the discriminative stimulus properties of d-amphetamine and cocaine. Psychopharmacology (Berl) 103:50-5
Appel, J B; Baker, L E; Barrett, R L et al. (1991) Use of drug discrimination in drug abuse research. NIDA Res Monogr :369-97
Callahan, P M; Appel, J B (1990) Differentiation between the stimulus effects of (+)-lysergic acid diethylamide and lisuride using a three-choice, drug discrimination procedure. Psychopharmacology (Berl) 100:13-8
Appel, J B; Callahan, P M (1989) Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline. Eur J Pharmacol 159:41-6
Barrett, R L; Appel, J B (1989) Effects of stimulation and blockade of dopamine receptor subtypes on the discriminative stimulus properties of cocaine. Psychopharmacology (Berl) 99:13-6
Callahan, P M; Appel, J B (1988) Differences in the stimulus properties of 3,4-methylenedioxyamphetamine and 3,4- methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline. J Pharmacol Exp Ther 246:866-70
Appel, J B; Weathersby, R T; Cunningham, K A et al. (1988) Stimulus properties of dopaminergic drugs: comparisons involving selective agonists and antagonists. Psychopharmacol Ser 4:44-56

Showing the most recent 10 out of 23 publications