Abstract

The experiments are aimed at a better understanding of: 1) Brain stem sites and transmitters involved in nociception and antinociception; 2) morphine's interaction with transmitters at extra hypothalamic sites for the secretion of luteinizing hormone; and 3) the role played by substance P in nociception and antinociception. The experiments employ: intracerebral drug microinjections; electrophysiologic/microiontophoretic drug evaluations, and assays for tissue contents of serotonin, norepinephrine, substance P and luteinizing hormone.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA002879-09
Application #
3207601
Study Section
(DABA)
Project Start
1981-09-30
Project End
1987-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Hemovich, Vanessa; Crano, William D (2009) Family structure and adolescent drug use: an exploration of single-parent families. Subst Use Misuse 44:2099-113
Buhler, A V; Proudfit, H K; Gebhart, G F (2008) Neurotensin-produced antinociception in the rostral ventromedial medulla is partially mediated by spinal cord norepinephrine. Pain 135:280-90
Tillu, D V; Gebhart, G F; Sluka, K A (2008) Descending facilitatory pathways from the RVM initiate and maintain bilateral hyperalgesia after muscle insult. Pain 136:331-9
Morgan, James R; Gebhart, G F (2008) Characterization of a model of chronic orofacial hyperalgesia in the rat: contribution of NA(V) 1.8. J Pain 9:522-31
Locher-Claus, Maria T; Erickson, Ty E; Law, Alan S et al. (2005) Effects of pre-emptive morphine, ibuprofen or local anesthetic on fos expression in the spinal trigeminal nucleus following tooth pulp exposure in the rat. J Endod 31:578-83
Gebhart, G F (2004) Descending modulation of pain. Neurosci Biobehav Rev 27:729-37
Buhler, A V; Proudfit, H K; Gebhart, G F (2004) Separate populations of neurons in the rostral ventromedial medulla project to the spinal cord and to the dorsolateral pons in the rat. Brain Res 1016:12-9
Friedrich, Ann E; Gebhart, G F (2003) Modulation of visceral hyperalgesia by morphine and cholecystokinin from the rat rostroventral medial medulla. Pain 104:93-101
Hartwig, Andrew C; Mathias, Sarah I; Law, Alan S et al. (2003) Characterization and opioid modulation of inflammatory temporomandibular joint pain in the rat. J Oral Maxillofac Surg 61:1302-9
Zhuo, M; Sengupta, J N; Gebhart, G F (2002) Biphasic modulation of spinal visceral nociceptive transmission from the rostroventral medial medulla in the rat. J Neurophysiol 87:2225-36

Showing the most recent 10 out of 121 publications