Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA003699-05
Application #
3208278
Study Section
Pharmacology I Research Subcommittee (DABR)
Project Start
1984-07-01
Project End
1990-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Lee, C H; Dixon, J F; Reichman, M et al. (1992) Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not in gu Biochem J 282 ( Pt 2):377-85
Reichman, M; Nen, W; Hokin, L E (1991) Delta 9-tetrahydrocannabinol inhibits arachidonic acid acylation of phospholipids and triacylglycerols in guinea pig cerebral cortex slices. Mol Pharmacol 40:547-55
Rana, R S; Hokin, L E (1990) Role of phosphoinositides in transmembrane signaling. Physiol Rev 70:115-64
Reichman, M; Nen, W; Hokin, L E (1988) Delta 9-tetrahydrocannabinol increases arachidonic acid levels in guinea pig cerebral cortex slices. Mol Pharmacol 34:823-8
Hokin, L E; Dixon, J F; Reichman, M et al. (1987) Biochemical aspects of the phosphoinositide signalling system with special reference to the formation of inositol cyclic phosphates and arachidonic acid and metabolites on agonist stimulation. Adv Enzyme Regul 26:117-32
Sekar, M C; Dixon, J F; Hokin, L E (1987) The formation of inositol 1,2-cyclic 4,5-trisphosphate and inositol 1,2-cyclic 4-bisphosphate on stimulation of mouse pancreatic minilobules with carbamylcholine. J Biol Chem 262:340-4
Reichman, M; Nen, W; Hokin, L E (1987) Acetylcholine releases prostaglandins from brain slices incubated in vitro. J Neurochem 49:1216-21
Reichman, M; Nen, W; Hokin, L E (1987) Effects of delta 9-tetrahydrocannabinol on prostaglandin formation in brain. Mol Pharmacol 32:686-90
Reichman, M; Nen, W; Hokin, L E (1987) Highly sensitive muscarinic receptors in the cerebellum are coupled to prostaglandin formation. Biochem Biophys Res Commun 146:1256-61
Sekar, M C; Hokin, L E (1986) Phosphoinositide metabolism and cGMP levels are not coupled to the muscarinic-cholinergic receptor in human erythrocyte. Life Sci 39:1257-62

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