The proposed project will be a five-year continuation of a four- year grant designed to investigate parent, sibling, and peer influence on adolescent use of cigarettes, alcohol, marijuana, and smokeless tobacco. A sample of 763 families was initially recruited who are currently completing their third annual assessment. Measures included questionnaires completed by all members of the family over the age of 11 and living at home. More intensive investigations were conducted with a subset of the families who participated in individual interviews and parent- adolescent problem-solving interactions. The proposed research is designed to extend this longitudinal data set to late adolescence and young adulthood with the following aims. (a) To chart the developmental process of substance use in these age groups; (b) to identify familial, personal, and peer risk and protective factors that predictive of the onset and maintenance of substance use in adolescence and adulthood, (c) to examine the consequences of substance use and its reciprocal effects on socio-cognitive and behavioral factors, (d) within a mutiple-cohort design, to follow five cohorts over an eight-year period to separate historical from development effects, and (e) to contrast different theoretical models of the acquisition and progression of drug use.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA003706-05
Application #
3208288
Study Section
Drug Abuse Epidemiology and Prevention Research Review Committee (DAPA)
Project Start
1984-07-01
Project End
1993-06-30
Budget Start
1988-08-01
Budget End
1989-06-30
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Oregon Research Institute
Department
Type
DUNS #
053615423
City
Eugene
State
OR
Country
United States
Zip Code
97403
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69
Bergen, Andrew W; Michel, Martha; Nishita, Denise et al. (2015) Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption. PLoS One 10:e0126113
Stephens, Sarah H; Hartz, Sarah M; Hoft, Nicole R et al. (2013) Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. Genet Epidemiol 37:846-59
Hartz, Sarah M; Short, Susan E; Saccone, Nancy L et al. (2012) Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry 69:854-60
Brigham, Janet; Lessov-Schlaggar, Christina N; Javitz, Harold S et al. (2010) Validity of recall of tobacco use in two prospective cohorts. Am J Epidemiol 172:828-35
Hardin, Jill; He, Yungang; Javitz, Harold S et al. (2009) Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. Cancer Epidemiol Biomarkers Prev 18:3399-406
He, Yungang; Bergen, Andrew W; Hops, Hyman et al. (2009) Genome-wide linkage of cotinine pharmacokinetics suggests candidate regions on chromosomes 9 and 11. Am J Med Genet B Neuropsychiatr Genet 150B:554-9
Bergen, Andrew W; Conti, David V; Van Den Berg, David et al. (2009) Dopamine genes and nicotine dependence in treatment-seeking and community smokers. Neuropsychopharmacology 34:2252-64
Lessov-Schlaggar, Christina N; Hops, Hyman; Brigham, Janet et al. (2008) Adolescent smoking trajectories and nicotine dependence. Nicotine Tob Res 10:341-51
Ozechowski, Timothy J; Turner, Charles W; Hops, Hyman (2007) Mixed-effects logistic regression for estimating transitional probabilities in sequentially coded observational data. Psychol Methods 12:317-35

Showing the most recent 10 out of 25 publications