Cocaine abuse is a major public health problem in the United States with no accepted pharmacologic treatment. We propose a placebo-controlled, randomized, double-blind outpatient study evaluating imipramine as a treatment for cocaine abuse in 80 chronic users. The study is designed to: 1) determine the efficacy of imipramine as an outpatient medication treatment for cocaine abuse 2) determine the efficacy of imipramine in blocking the cocaine euphoria and/or diminishing the craving for cocaine in abusers 3) examine the physiologic response to cocaine via a controlled laboratory challenge with cocaine before and after imipramine 4) determine the prevalence and types of psychiatric disorders in chronic cocaine abusers and contribute to the determination of whether """"""""cocaine dependence"""""""" should be a part of the official nosology of mental disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA003836-02
Application #
3208576
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1986-07-01
Project End
1989-06-30
Budget Start
1987-08-01
Budget End
1988-06-30
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Nunes, E V (1997) Methodologic recommendations for cocaine abuse clinical trials: a clinician-researcher's perspective. NIDA Res Monogr 175:73-95
Nunes, E V; McGrath, P J; Quitkin, F M et al. (1995) Imipramine treatment of cocaine abuse: possible boundaries of efficacy. Drug Alcohol Depend 39:185-95
Nunes, E V; McGrath, P J; Wager, S et al. (1990) Lithium treatment for cocaine abusers with bipolar spectrum disorders. Am J Psychiatry 147:655-7
Nunes, E V; Quitkin, F M; Klein, D F (1989) Psychiatric diagnosis in cocaine abuse. Psychiatry Res 28:105-14