The proposed analyses will deepen our understanding of the possible reproductive effects of selected drugs subject to misuse by extending observations to spontaneous abortions of known chromosomal characteristics. The relations of maternal exposure to marijuana, heroin, methadone, cocaine, diazepam and phenylpropanolamine (PPA) to chromosomally normal spontaneous abortions and to chromosomally abnormal spontaneous abortions of various types (e.g. trisomy, monosomy X, triploidy) will be assessed. In addition, the relation of paternal marijuana use to spontaneous abortion, defined by karyotype of the abortus, and of maternal marijuana use to intrauterine growth retardation and preterm delivery will be examined. The data derive from a combined epidemiologic, cytogenetic and pathologic study of spontaneous abortions. Systematic medication and drug use histories have been obtained over a 12 year period from a consecutive series of women seeking hospital care for spontaneous abortion (cases) and controls. In total data from about 2700 women with spontaneous abortions of known karyotype and 4600 controls are available for the proposed analyses. These already collected data provide a unique opportunity to extend observations on the possible relations of drug abuse to reproduction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA004186-01
Application #
3209464
Study Section
Drug Abuse Epidemiology and Prevention Research Review Committee (DAPA)
Project Start
1986-09-01
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Sackoff, J; Kline, J; Susser, M (1994) Previous use of oral contraceptives and spontaneous abortion. Epidemiology 5:422-8
Kline, J; Hutzler, M; Levin, B et al. (1991) Marijuana and spontaneous abortion of known karyotype. Paediatr Perinat Epidemiol 5:320-32
Stein, A D; Kline, J (1991) Pre-pregnant body size and spontaneous abortion of known karyotype. Early Hum Dev 25:173-80