Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004274-09
Application #
2117111
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1987-02-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Pharmacology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Stone, Laura S; German, Jonathan P; Kitto, Kelly F et al. (2014) Morphine and clonidine combination therapy improves therapeutic window in mice: synergy in antinociceptive but not in sedative or cardiovascular effects. PLoS One 9:e109903
Stone, Laura S; Kitto, Kelley F; Eisenach, James C et al. (2007) ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors. J Pharmacol Exp Ther 323:899-906
Laughlin, T M; Bethea, J R; Yezierski, R P et al. (2000) Cytokine involvement in dynorphin-induced allodynia. Pain 84:159-67
Fairbanks, C A; Nguyen, H O; Grocholski, B M et al. (2000) Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice. Anesthesiology 93:765-73
Fairbanks, C A; Posthumus, I J; Kitto, K F et al. (2000) Moxonidine, a selective imidazoline/alpha(2) adrenergic receptor agonist, synergizes with morphine and deltorphin II to inhibit substance P-induced behavior in mice. Pain 84:13-20
Fairbanks, C A; Wilcox, G L (2000) Spinal plasticity of acute opioid tolerance. J Biomed Sci 7:200-12
Fairbanks, C A; Wilcox, G L (1999) Moxonidine, a selective alpha2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice. J Pharmacol Exp Ther 290:403-12
Fairbanks, C A; Wilcox, G L (1999) Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine. J Pharmacol Exp Ther 288:1107-16
Laughlin, T M; Kitto, K F; Wilcox, G L (1999) Redox manipulation of NMDA receptors in vivo: alteration of acute pain transmission and dynorphin-induced allodynia. Pain 80:37-43
Fairbanks, C A; Wilcox, G L (1997) Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance. J Pharmacol Exp Ther 282:1408-17

Showing the most recent 10 out of 33 publications