Abstract

We propose a two year, two part screening/interview and prospective followup study of HTLV-III infection in heterosexual intravenous drug users (IVDUs) in San Francisco, in collaboration with major treatment programs. 1. Screening/interview study. We will screen 1000-1200 IVDUs in each year of study, including one third of the annual treatment program intake, by ELISA with Western Blot confirmation. Subjects will be interviewed for demographics and risk factors by ourselves and collaborators. We will obtain (1) serial measurement of HTLV-III prevalence in the city and in specific programs; (2) assessment of risk-reduction interventions; (3) identification of behavioral risk factors; and (4) recruitment of seropositives for prospective study. 2. Prospective study. We will accumulate a cohort of 150 IVDUs and matched seronegative controls and follow them at 6-8 month intervals for clinical and laboratory status. We will (1) analyze rates of progression to clinical AIDS, ARC, and immune abnormalities; (2) explore cofactors and predictors of pregression; and (3) compare the natural history of HTLV-III infection in IVDUs with our parallel cohort of seropositive homosexual men.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004363-02
Application #
3209917
Study Section
(SRCD)
Project Start
1986-09-30
Project End
1988-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Hahn, Judith A; Kushel, Margot B; Bangsberg, David R et al. (2006) BRIEF REPORT: the aging of the homeless population: fourteen-year trends in San Francisco. J Gen Intern Med 21:775-8
Hahn, Judith A; Bangsberg, David R; McFarland, William et al. (2004) HIV seroconversion among the homeless and marginally housed in San Francisco: a ten-year study. J Acquir Immune Defic Syndr 37:1616-9
Moss, A R; Hahn, J A; Tulsky, J P et al. (2000) Tuberculosis in the homeless. A prospective study. Am J Respir Crit Care Med 162:460-4
Hahn, J A; Vranizan, K M; Moss, A R (1997) Who uses needle exchange? A study of injection drug users in treatment in San Francisco, 1989-1990. J Acquir Immune Defic Syndr Hum Retrovirol 15:157-64
Pilote, L; Tulsky, J P; Zolopa, A R et al. (1996) Tuberculosis prophylaxis in the homeless. A trial to improve adherence to referral. Arch Intern Med 156:161-5
Zolopa, A R; Hahn, J A; Gorter, R et al. (1994) HIV and tuberculosis infection in San Francisco's homeless adults. Prevalence and risk factors in a representative sample. JAMA 272:455-61
Shiboski, C H; Hilton, J F; Greenspan, D et al. (1994) HIV-related oral manifestations in two cohorts of women in San Francisco. J Acquir Immune Defic Syndr 7:964-71
Moss, A R; Vranizan, K; Gorter, R et al. (1994) HIV seroconversion in intravenous drug users in San Francisco, 1985-1990. AIDS 8:223-31
Moss, A R; Vranizan, K (1992) Charting the epidemic: the case study of HIV screening of injecting drug users in San Francisco, 1985-1990. Br J Addict 87:467-71
Wolfe, H; Vranizan, K M; Gorter, R G et al. (1992) Crack use and human immunodeficiency virus infection among San Francisco intravenous drug users. Sex Transm Dis 19:111-4

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