This proposal involves the clinical testing of a pharmacologic agent in a smoking cessation trial. Clonidine, an alpha-2 agonist, has been shown to reduce symptoms in both acute opiate and alcohol withdrawal. Recently, it has been shown to reduce acute nicotine withdrawal as well. This proposal will test whether clonidine's ability to alter nicotine withdrawal is associated with an in- creased rate of success among a group of heavy cigarette smokers participating in a smoking cessation program. By use of a double- blind, placebo-controlled random assignment design, this proposal will test the ability of clonidine compared to a placebo to facilitate smoking cessation during a ten week treatment program and to examine if any meaningful advantage persists one year after the end of treatment. In addition, this proposal will test the hypothesis, that a past history of major affective disorder is a predictor of treatment outcome in smoking cessation and will explore the implications this has for new pharmacological treatment strategies in this group. The significance of this project stems from the enormous health hazard associated with cigarette smoking. Clonidine appears to be a new and promising aid to smoking cessation in heavy smokers who have tried to stop and failed on numerous other occasions. Among this group of severely addicted smokers our most successful presently available interventions have been, at best, seriously limited.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA004732-01A1
Application #
3210397
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1989-01-01
Project End
1992-12-31
Budget Start
1989-01-01
Budget End
1989-12-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
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Stage, K B; Glassman, A H; Covey, L S (1996) Depression after smoking cessation: case reports. J Clin Psychiatry 57:467-9
Dalack, G W; Glassman, A H; Rivelli, S et al. (1995) Mood, major depression, and fluoxetine response in cigarette smokers. Am J Psychiatry 152:398-403
Mooney, L A; Santella, R M; Covey, L et al. (1995) Decline of DNA damage and other biomarkers in peripheral blood following smoking cessation. Cancer Epidemiol Biomarkers Prev 4:627-34
Glassman, A H (1993) Cigarette smoking: implications for psychiatric illness. Am J Psychiatry 150:546-53
Glassman, A H; Covey, L S; Dalack, G W et al. (1993) Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers. Clin Pharmacol Ther 54:670-9
Covey, L S; Glassman, A H; Stetner, F et al. (1993) Effect of history of alcoholism or major depression on smoking cessation. Am J Psychiatry 150:1546-7

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