Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004758-08
Application #
2117286
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1988-08-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Selken, Jennifer; Nichols, David E (2007) Alpha1-adrenergic receptors mediate the locomotor response to systemic administration of (+/-)-3,4-methylenedioxymethamphetamine (MDMA) in rats. Pharmacol Biochem Behav 86:622-30
Kanthasamy, A; Sprague, J E; Shotwell, J R et al. (2002) Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum. Neuroscience 114:917-24
Sprague, J E; Worst, T J; Haynes, K et al. (2001) The pharmacodynamic characterization of an antisense oligonucleotide against monoamine oxidase-B (MAO-B) in rat brain striatal tissue. Cell Mol Neurobiol 21:53-64
Parker, M A; Marona-Lewicka, D; Kurrasch, D et al. (1998) Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA). J Med Chem 41:1001-5
Marona-Lewicka, D; Nichols, D E (1998) Drug discrimination studies of the interoceptive cues produced by selective serotonin uptake inhibitors and selective serotonin releasing agents. Psychopharmacology (Berl) 138:67-75
Cozzi, N V; Frescas, S; Marona-Lewicka, D et al. (1998) Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential. Pharmacol Biochem Behav 59:709-15
Sprague, J E; Everman, S L; Nichols, D E (1998) An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicology 19:427-41
Marona-Lewicka, D; Nichols, D E (1997) 5-HT2A/2C receptor agonists potentiate the discriminative cue of (+)-amphetamine in the rat. Neuropharmacology 36:1471-5
Marona-Lewicka, D; Rhee, G S; Sprague, J E et al. (1996) Reinforcing effects of certain serotonin-releasing amphetamine derivatives. Pharmacol Biochem Behav 53:99-105
Sprague, J E; Nichols, D E (1995) The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. J Pharmacol Exp Ther 273:667-73

Showing the most recent 10 out of 30 publications