Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA004905-01A2
Application #
3210719
Study Section
Pharmacology I Research Subcommittee (DABR)
Project Start
1989-09-30
Project End
1992-08-31
Budget Start
1989-09-30
Budget End
1990-08-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Olsen, G D; Weil, J A (1995) Neonatal ventilatory changes following in utero cocaine exposure: a minireview of the guinea pig and rabbit models. Neurotoxicology 16:153-7
Olsen, G D (1995) Placental permeability for drugs of abuse and their metabolites. NIDA Res Monogr 154:152-62
Olsen, G D; Murphey, L J (1995) Effects of morphine and cocaine on breathing control in neonatal animals: a minireview. NIDA Res Monogr 158:22-39
Sandberg, J A; Murphey, L J; Olsen, G D (1995) Pharmacokinetics and metabolism of cocaine in maternal and fetal guinea pigs. Neurotoxicology 16:169-77
Konkol, R J; Murphey, L J; Ferriero, D M et al. (1994) Cocaine metabolites in the neonate: potential for toxicity. J Child Neurol 9:242-8
Murphey, L J; Olsen, G D (1994) Morphine-6-beta-D-glucuronide respiratory pharmacodynamics in the neonatal guinea pig. J Pharmacol Exp Ther 268:110-6
Murphey, L J; Olsen, G D (1994) Diffusion of morphine-6-beta-D-glucuronide into the neonatal guinea pig brain during drug-induced respiratory depression. J Pharmacol Exp Ther 271:118-24
Sandberg, J A; Murphey, L J; Olsen, G D (1993) In vitro hepatic biotransformation of cocaine in maternal and fetal guinea pigs. Induction of cocaine N-demethylation with cocaine pretreatment. Drug Metab Dispos 21:390-5
Murphey, L J; Olsen, G D; Konkol, R J (1993) Quantitation of benzoylnorecgonine and other cocaine metabolites in meconium by high-performance liquid chromatography. J Chromatogr 613:330-5
Sandberg, J A; Olsen, G D (1992) Cocaine and metabolite concentrations in the fetal guinea pig after chronic maternal cocaine administration. J Pharmacol Exp Ther 260:587-91

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