The majority of extant studies of the long-term consequences of adolescent drug abuse have been based on random samples drawn from the general population. Because these studies have low rates of clinical-level drug abusing adolescents, little is known about the long-term consequences of adolescent drug abuse. This revision of a continuation study of DA05104 proposes to focus on the description of the long-term outcomes, including drug abuse, patterns of relapse, and level of functioning in a young adult sample with a DSM-IV lifetime diagnosis of at least one substance use disorder. This target group will consist of 195 participants, aged 20-23. A control sample of normal young adults (n-130) matched for age, ethnicity, and educational status will provide a comparison group. The following specific aims will be addressed:
Aim 1 : To describe the long-term (4 years) drug involvement severity and other psychosocial outcomes, including the comparison of the target (clinical) group and a control (normal) group. Such descriptions of a clinical drug-abusing adolescent sample, supplemented by a comparison to a matched control group, will provide invaluable contributions to the field regarding questions of the course of drug use and other problem areas from adolescence to young adulthood.
Aim 2 : To examine the relationship of prior drug involvement severity and psychosocial functioning to young adult outcomes in these domains. It is hypothesized that greater prior drug abuse and psychosocial risk will be associated with poorer psychosocial and health functioning (e.g., less educational attainment and more interpersonal problems), and more instances of continued drug abuse and co-morbid psychiatric disorders.
Aim 3 : To examine the relationship of prior drug involvement and psychosocial risk and developmental outcomes. It is hypothesized that greater prior drug use and psychosocial risk will be associated with poorer results on the developmental outcome measures.
Aim 4 : To evaluate the appropriateness of a model of post-treatment outcome adapted from the adult literature and alcohol adolescent literature to explain outcome patterns at year-1 and year-4.
Aim 5 : To describe the antecedents of drug use lapse and relapse in the young adult target sample at year 4.
| Winters, Ken C; Kaminer, Yifrah (2008) Screening and assessing adolescent substance use disorders in clinical populations. J Am Acad Child Adolesc Psychiatry 47:740-4 |
| Winters, Ken C; Stinchfield, Randy D; Lee, Susanne et al. (2008) Interplay of psychosocial factors and the long-term course of adolescents with a substance use disorder. Subst Abus 29:107-19 |
| Winters, Ken C; Stinchfield, Randy D; Latimer, William W et al. (2008) Internalizing and externalizing behaviors and their association with the treatment of adolescents with substance use disorder. J Subst Abuse Treat 35:269-78 |
| Brown, Sandra A; McGue, Matthew; Maggs, Jennifer et al. (2008) A developmental perspective on alcohol and youths 16 to 20 years of age. Pediatrics 121 Suppl 4:S290-310 |
| Chung, Tammy; Martin, Christopher S; Winters, Ken C (2005) Diagnosis, course, and assessment of alcohol abuse and dependence in adolescents. Recent Dev Alcohol 17:5-27 |
| Chung, Tammy; Martin, Christopher S; Winters, Ken C et al. (2004) Limitations in the assessment of DSM-IV cannabis tolerance as an indicator of dependence in adolescents. Exp Clin Psychopharmacol 12:136-46 |
| Chung, Tammy; Martin, Christopher S; Grella, Christine E et al. (2003) Course of alcohol problems in treated adolescents. Alcohol Clin Exp Res 27:253-61 |
| Clark, Duncan B; Winters, Ken C (2002) Measuring risks and outcomes in substance use disorders prevention research. J Consult Clin Psychol 70:1207-23 |
| Chung, T; Martin, C S; Winters, K C et al. (2001) Assessment of alcohol tolerance in adolescents. J Stud Alcohol 62:687-95 |
| Latimer, W W; Newcomb, M; Winters, K C et al. (2000) Adolescent substance abuse treatment outcome: the role of substance abuse problem severity, psychosocial, and treatment factors. J Consult Clin Psychol 68:684-96 |
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