Most of the research involving the prenatal cocaine exposure has been conducted on young children and young animals. Research on long term consequences of prenatal cocaine exposure in humans will not be forthcoming for many years. We may be able to anticipate such long-term morbidities through animal studies, but as yet there are few relevant studies from which one can make inferences. Those which have been conducted suggest that animals prenatally exposed to drugs show a changing pattern of impairment across their lifespan, particularly with respect to cognitive and physical abilities. We propose as in-depth evaluation of select morbidities across the lifespan in an anima model of prenatal cocaine exposure. To this end we will study brain electrophysiology/sensory function, enhanced stress responsibility, circadian variations in activity levels, physical maturation and life-span. The subjects will be the offspring of female rats who have received either 20 or 40 mg/kg cocaine HCI twice daily (s.c.) from gestation days 7-20, inclusively. Untreated and pair-fed/saline-injected control groups will also be used. All litters will be removed at birth and placed with non-treated surrogate dams to eliminate possible confounding between gestational cocaine administration and postnatal residual effects on maternal behavior or lactational performance. The offspring will be evaluated at different stages of their lifespan This study will advance our understanding about the long-term effects of in utero cocaine exposure.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA005536-09
Application #
2749044
Study Section
Special Emphasis Panel (SRCD (57))
Project Start
1987-09-30
Project End
1999-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Wayne State University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Church, Michael W; Holmes, Pamela A; Tilak, Jacqueline P et al. (2004) Prenatal cocaine exposure influences the growth and life span of laboratory rats. Neurotoxicol Teratol 26:429-41
Church, Michael W; Blakley, Brian W; Burgio, Don L et al. (2004) WR-2721 (Amifostine) ameliorates cisplatin-induced hearing loss but causes neurotoxicity in hamsters: dose-dependent effects. J Assoc Res Otolaryngol 5:227-37
Church, M W; Crossland, W J; Holmes, P A et al. (1998) Effects of prenatal cocaine on hearing, vision, growth, and behavior. Ann N Y Acad Sci 846:12-28
Church, M W; Abel, E L (1998) Fetal alcohol syndrome. Hearing, speech, language, and vestibular disorders. Obstet Gynecol Clin North Am 25:85-97
Church, M W; Eldis, F; Blakley, B W et al. (1997) Hearing, language, speech, vestibular, and dentofacial disorders in fetal alcohol syndrome. Alcohol Clin Exp Res 21:227-37
Church, M W; Subramanian, M G (1997) Cocaine's lethality increases during late gestation in the rat: a study of ""critical periods"" of exposure. Am J Obstet Gynecol 176:901-6
Kaltenbach, J A; Church, M W; Blakley, B W et al. (1997) Comparison of five agents in protecting the cochlea against the ototoxic effects of cisplatin in the hamster. Otolaryngol Head Neck Surg 117:493-500
Church, M W; Kaltenbach, J A (1997) Hearing, speech, language, and vestibular disorders in the fetal alcohol syndrome: a literature review. Alcohol Clin Exp Res 21:495-512
Church, M W; Kaltenbach, J A; Blakley, B W et al. (1995) The comparative effects of sodium thiosulfate, diethyldithiocarbamate, fosfomycin and WR-2721 on ameliorating cisplatin-induced ototoxicity. Hear Res 86:195-203
Bilitzke, P J; Church, M W (1992) Prenatal cocaine and alcohol exposures affect rat behavior in a stress test (the Porsolt swim test). Neurotoxicol Teratol 14:359-64

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