Mechanism of Adenylyl Cyclase Superactivation by Opiates

Vogel, Zvi

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Drug Abuse (NIDA)
• Type: Research Project (R01)
• Project #: 5R01DA006265-09
• Application #: 6515434
• Study Section: Special Emphasis Panel (ZRG1-MDCN-5 (01))
• Program Officer: Lin, Geraline
• Project Start: 1990-03-01
• Project End: 2004-08-31
• Budget Start: 2002-04-01
• Budget End: 2004-08-31
• Support Year: 9
• Fiscal Year: 2002
• Total Cost: $106,739

Institution

• Name: Weizmann Institute of Science
• City: Rehovot
• Country: Israel
• Zip Code: 76100

Publications

Schallmach, Ester; Steiner, Debora; Vogel, Zvi (2006) Adenylyl cyclase type II activity is regulated by two different mechanisms: implications for acute and chronic opioid exposure. Neuropharmacology 50:998-1005

Steiner, Debora; Saya, Daniella; Schallmach, Ester et al. (2006) Adenylyl cyclase type-VIII activity is regulated by G(betagamma) subunits. Cell Signal 18:62-8

Schallmach, Ester; Steiner, Debora; Vogel, Zvi (2006) Inhibition of AC-II activity following chronic agonist exposure is modulated by phosphorylation. J Mol Neurosci 29:115-22

Steiner, Debora; Avidor-Reiss, Tomer; Schallmach, Ester et al. (2005) Regulation of adenylate cyclase type VIII splice variants by acute and chronic Gi/o-coupled receptor activation. Biochem J 386:341-8

Steiner, Debora; Avidor-Reiss, Tomer; Schallmach, Ester et al. (2005) Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers. J Mol Neurosci 27:195-203

Nevo, I; Avidor-Reiss, T; Levy, R et al. (2000) Acute and chronic activation of the mu-opioid receptor with the endogenous ligand endomorphin differentially regulates adenylyl cyclase isozymes. Neuropharmacology 39:364-71

Bayewitch, M L; Nevo, I; Avidor-Reiss, T et al. (2000) Alterations in detergent solubility of heterotrimeric G proteins after chronic activation of G(i/o)-coupled receptors: changes in detergent solubility are in correlation with onset of adenylyl cyclase superactivation. Mol Pharmacol 57:820-5

Eckhardt, K; Nevo, I; Levy, R et al. (2000) Morphine-related metabolites differentially activate adenylyl cyclase isozymes after acute and chronic administration. FEBS Lett 470:309-14

Bayewitch, M L; Avidor-Reiss, T; Levy, R et al. (1998) Differential modulation of adenylyl cyclases I and II by various G beta subunits. J Biol Chem 273:2273-6

Rhee, M H; Bayewitch, M; Avidor-Reiss, T et al. (1998) Cannabinoid receptor activation differentially regulates the various adenylyl cyclase isozymes. J Neurochem 71:1525-34