""""""""Crack"""""""" cocaine abuse often produces severe cocaine dependence that is refractory to available pharmacological and outpatient psychotherapeutic treatments. In an open pilot trial, we evaluated the efficacy o a depot xanthene requiring infrequent IM administration, flupenthixol decanoate, for cocaine withdrawal. Ten poor prognosis, outpatient """"""""crack"""""""" cocain smokers were administered flupenthixol decanoate in an open-label, open- ended trial. flupenthixol decanoate was well tolerated, and appeared to markedly and rapidly decrease cocaine craving and use, producing a 260% per cent increase over prior treatment in these subjects in their average time retained in treatment. This application proposes a double-blind flupenthixol decanoate trial with a comparison to a current oral pharmacotherapy, desipramine. Ninety """"""""crack"""""""" cocain abusers will be treated in a clinical trial with randomized treatment comparing three contrasting pharmacological treatments added to conventional psychotherapy: (a) Placebo Desipramine plus Placebo I.M. Flupenthixol de==Decanoate (n=30) (b) Desipramine plus Placebo I. M. Flupenthixol Decanoate (n=30). Outcomes will be multidimensional. Twelve month follow- up evaluations will be performed to evaluate the durability and/or delayed emergence of treatment effects.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA006289-03
Application #
3212926
Study Section
Special Emphasis Panel (SRCD (22))
Project Start
1990-12-10
Project End
1993-01-31
Budget Start
1991-02-01
Budget End
1992-01-31
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Friends Research Institute, Inc.
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Gawin, F H (1991) Cocaine addiction: psychology and neurophysiology. Science 251:1580-6