Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA006601-07
Application #
2118794
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1989-09-30
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Physiology
Type
Schools of Veterinary Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Ndikum-Moffor, Florence M; Roberts, Stephen M (2003) Cocaine-protein targets in mouse liver. Biochem Pharmacol 66:105-13
Boess, F; Ndikum-Moffor, F M; Boelsterli, U A et al. (2000) Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species. Biochem Pharmacol 60:615-23
Ndikum-Moffor, F M; Munson, J W; Bokinkere, N K et al. (1998) Immunochemical detection of hepatic cocaine-protein adducts in mice. Chem Res Toxicol 11:185-92
Ndikum-Moffor, F M; Schoeb, T R; Roberts, S M (1998) Liver toxicity from norcocaine nitroxide, an N-oxidative metabolite of cocaine. J Pharmacol Exp Ther 284:413-9
Roberts, S M; Phillips, D L; Tebbett, I R (1995) Increased blood and brain cocaine concentrations with ethanol cotreatment in mice. Drug Metab Dispos 23:664-6
Roberts, S M; Harbison, R D; James, R C (1993) Inhibition by ethanol of the metabolism of cocaine to benzoylecgonine and ecgonine methyl ester in mouse and human liver. Drug Metab Dispos 21:537-41
Roberts, S M; Roth, L; Harbison, R D et al. (1992) Cocaethylene hepatotoxicity in mice. Biochem Pharmacol 43:1989-95
Roth, L; Harbison, R D; James, R C et al. (1992) Cocaine hepatotoxicity: influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis. Hepatology 15:934-40
Roberts, S M; Munson, J W; James, R C et al. (1992) An assay for cocaethylene and other cocaine metabolites in liver using high-performance liquid chromatography. Anal Biochem 202:256-61
Roberts, S M; Harbison, R D; James, R C (1991) Human microsomal N-oxidative metabolism of cocaine. Drug Metab Dispos 19:1046-51