Abstract

The long term objective of the present proposal is to help clarify the question of how opiate analgesics relieve pain. There are several loci in brain where opiate receptors are located and where electrical and/or chemical (opiate) activation produces analgesia. These structures connect to pain pathways along multiple routes. A systemic injection of opiates must activate many of these substrates in a complex dynamic manner. The approach proposed is to examine effects of single and conjoint activation of two opiate substrates in rat, the midbrain periacqueductal gray (PAG) and the nucleus reticularis paragigantocellularis (PGC), on recorded responses of single neurons in nucleus raphe magnus (NRM) and in trigeminal nucleus caudalis (TNC). Met-Enkephalin will be microcannulated into PAG and PGC singly and together and it will be determined whether or not (and if so, how) these two opiate substrates can influence the same cell in NRM, an opiate substrate itself; and in TNC, the origin of a pain pathway. Dose-response studies of the effects of morphine in PGC will also be done. Time permitting, effects of PGC lesions on PAG morphine-evoked modification of NRM and TNC unit activity will also be investigated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
9R01DA006971-04
Application #
3213671
Study Section
Sensory Disorders and Language Study Section (CMS)
Project Start
1986-08-01
Project End
1993-04-30
Budget Start
1990-06-01
Budget End
1991-04-30
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201