Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA007313-05
Application #
2013098
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1995-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Kopacz, D J; Bernards, C M (2001) Effect of clonidine on lidocaine clearance in vivo: a microdialysis study in humans. Anesthesiology 95:1371-6
Ummenhofer, W C; Arends, R H; Shen, D D et al. (2000) Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil. Anesthesiology 92:739-53
Bernards, C M; Ulma Jr, G A; Kopacz, D J (2000) The meningeal permeability of R- and S-bupivacaine are not different: evidence that pharmacodynamic differences between the enantiomers are not the result of differences in bioavailability. Anesthesiology 93:896-7
Ummenhofer, W C; Stapleton, A E; Bernards, C M (1999) Effect of Staphylococcus aureus bacteria and bacterial toxins on meningeal permeability in vitro. Reg Anesth Pain Med 24:24-9
Bernards, C M; Kopacz, D J (1999) Effect of epinephrine on lidocaine clearance in vivo: a microdialysis study in humans. Anesthesiology 91:962-8
Powers, K M; Schimmel, C; Glenny, R W et al. (1999) Cerebral blood flow determinations using fluorescent microspheres: variations on the sedimentation method validated. J Neurosci Methods 87:159-65
Ummenhofer, W C; Brown, S M; Bernards, C M (1998) Acetylcholinesterase and butyrylcholinesterase are expressed in the spinal meninges of monkeys and pigs. Anesthesiology 88:1259-65
Kern, C; Bernards, C M (1997) Ascorbic acid inhibits spinal meningeal catechol-o-methyl transferase in vitro, markedly increasing epinephrine bioavailability. Anesthesiology 86:405-9
Ummenhofer, W C; Bernards, C M (1997) Acylcarnitine chain length influences carnitine-enhanced drug flux through the spinal meninges in vitro. Anesthesiology 86:642-8
Kern, C; Mautz, D S; Bernards, C M (1995) Epinephrine is metabolized by the spinal meninges of monkeys and pigs. Anesthesiology 83:1078-81

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