Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA007496-04A1
Application #
2013107
Study Section
Human Development Research Subcommittee (NIDA)
Project Start
1992-08-01
Project End
2000-08-31
Budget Start
1996-09-29
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Chen, Jiang-Fan; Fredduzzi, Silva; Bastia, Elena et al. (2003) Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease. Neurology 61:S74-81
Chen, Jiang-Fan; Moratalla, Rosario; Yu, Liqun et al. (2003) Inactivation of adenosine A2A receptors selectively attenuates amphetamine-induced behavioral sensitization. Neuropsychopharmacology 28:1086-95
Fredduzzi, Silva; Moratalla, Rosario; Monopoli, Angela et al. (2002) Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors. J Neurosci 22:1054-62
Armstrong, J M; Chen, J F; Schwarzschild, M A et al. (2001) Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice. Biochem J 354:123-30
Chen, J F; Moratalla, R; Impagnatiello, F et al. (2001) The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proc Natl Acad Sci U S A 98:1970-5
Chen, J F; Beilstein, M; Xu, Y H et al. (2000) Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors. Neuroscience 97:195-204
Apasov, S G; Chen, J F; Smith, P T et al. (2000) Study of A(2A) adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A(2A) receptor-unrelated lymphotoxicity. Br J Pharmacol 131:43-50
Chen, J F; Huang, Z; Ma, J et al. (1999) A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J Neurosci 19:9192-200
Turgeon, S M; Pollack, A E; Fink, J S (1997) Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization. Brain Res 749:120-6
Pollack, A E; Turgeon, S M; Fink, J S (1997) Apomorphine priming alters the response of striatal outflow pathways to D2 agonist stimulation in 6-hydroxydopamine-lesioned rats. Neuroscience 79:79-93

Showing the most recent 10 out of 17 publications