Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA007859-04
Application #
2120294
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1992-03-13
Project End
1997-02-28
Budget Start
1995-03-01
Budget End
1997-02-28
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Coleman, D T; Chen, X; Sassaroli, M et al. (1996) Pituitary adenylate cyclase-activating polypeptide regulates prolactin promoter activity via a protein kinase A-mediated pathway that is independent of the transcriptional pathway employed by thyrotropin-releasing hormone. Endocrinology 137:1276-85
Gaiddon, C; Tian, J; Loeffler, J P et al. (1996) Constitutively active G(S) alpha-subunits stimulate Pit-1 promoter activity via a protein kinase A-mediated pathway acting through deoxyribonucleic acid binding sites both for Pit-1 and for adenosine 3',5'-monophosphate response element-binding protein. Endocrinology 137:1286-91
Gaiddon, C; Mercken, L; Bancroft, C et al. (1995) Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via Endocrinology 136:4331-8
Coleman, D T; Bancroft, C (1995) Nicotine acts directly on pituitary GH3 cells to inhibit prolactin promoter activity. J Neuroendocrinol 7:785-9
Tian, J; Ma, H W; Bancroft, C (1995) Constitutively active Gq-alpha stimulates prolactin promoter activity via a pathway involving Raf activity. Mol Cell Endocrinol 112:249-56
Tian, J; Chen, J; Bancroft, C (1994) Expression of constitutively active Gs alpha-subunits in GH3 pituitary cells stimulates prolactin promoter activity. J Biol Chem 269:33-6
Yan, G; Chen, X; Bancroft, C (1994) A constitutively active form of CREB can activate expression of the rat prolactin promoter in non-pituitary cells. Mol Cell Endocrinol 101:R25-30