Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA008094-03
Application #
2120573
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1993-09-01
Project End
1997-01-31
Budget Start
1995-08-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Arizona
Department
Other Health Professions
Type
Schools of Pharmacy
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Kakkar, T; Pak, Y; Mayersohn, M (2000) Evaluation of a minimal experimental design for determination of enzyme kinetic parameters and inhibition mechanism. J Pharmacol Exp Ther 293:861-9
Kakkar, T; Boxenbaum, H; Mayersohn, M (1999) Estimation of Ki in a competitive enzyme-inhibition model: comparisons among three methods of data analysis. Drug Metab Dispos 27:756-62
Chow, H H; Khor, S P; Lee, H C et al. (1998) A modified equilibrium dialysis technique for measuring plasma protein binding: experimental evaluation with diazepam and nortriptyline. Pharm Res 15:1643-6
Bourland, J A; Martin, D K; Mayersohn, M (1998) In vitro transesterification of cocaethylene (ethylcocaine) in the presence of ethanol. esterase-mediated ethyl ester exchange esterase-mediated ethyl ester exchange. Drug Metab Dispos 26:203-6
Kakkar, T; Mayersohn, M (1998) Simultaneous quantitative analysis of methyl salicylate, ethyl salicylate and salicylic acid from biological fluids using gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl 718:69-75
Tannenbaum, S; Boxenbaum, H; Mayersohn, M (1997) Allometric analysis of organ extraction ratios. J Pharm Sci 86:1319-20
Bourland, J A; Martin, D K; Mayersohn, M (1997) Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: preliminary in vitro findings using a rat liver preparation. J Pharm Sci 86:1494-6
Hutchaleelaha, A; Sukbuntherng, J; Mayersohn, M (1997) Simple apparatus for serial blood sampling in rodents permitting simultaneous measurement of locomotor activity as illustrated with cocaine. J Pharmacol Toxicol Methods 37:9-14
Hutchaleelaha, A; Chow, H H; Mayersohn, M (1997) Comparative pharmacokinetics and interspecies scaling of amphotericin B in several mammalian species. J Pharm Pharmacol 49:178-83
Sukbuntherng, J; Martin, D K; Pak, Y et al. (1996) Characterization of the properties of cocaine in blood: blood clearance, blood to plasma ratio, and plasma protein binding. J Pharm Sci 85:567-71

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