Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA008562-03
Application #
2121102
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1993-12-10
Project End
2000-12-31
Budget Start
1996-02-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Organized Research Units
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Grandy, David K (2007) Trace amine-associated receptor 1-Family archetype or iconoclast? Pharmacol Ther 116:355-90
Allen, R G; Peng, B; Pellegrino, M J et al. (2001) Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective prohormone convertase 2. J Neurosci 21:5864-70
Allen, C N; Jiang, Z G; Teshima, K et al. (1999) Orphanin-FQ/nociceptin (OFQ/N) modulates the activity of suprachiasmatic nucleus neurons. J Neurosci 19:2152-60
Slugg, R M; Ronnekleiv, O K; Grandy, D K et al. (1999) Activation of an inwardly rectifying K+ conductance by orphanin-FQ/nociceptin in vasopressin-containing neurons. Neuroendocrinology 69:385-96
Tian, J H; Zhang, W; Fang, Y et al. (1998) Endogenous orphanin FQ: evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture. Br J Pharmacol 124:21-6
Wagner, E J; Ronnekleiv, O K; Grandy, D K et al. (1998) The peptide orphanin FQ inhibits beta-endorphin neurons and neurosecretory cells in the hypothalamic arcuate nucleus by activating an inwardly-rectifying K+ conductance. Neuroendocrinology 67:73-82
Quigley, D I; McDougall, J; Darland, T et al. (1998) Orphanin FQ is the major OFQ1-17-containing peptide produced in the rodent and monkey hypothalamus. Peptides 19:133-9
Morgan, M M; Grisel, J E; Robbins, C S et al. (1997) Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. Neuroreport 8:3431-4
Heinricher, M M; McGaraughty, S; Grandy, D K (1997) Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla. J Neurophysiol 78:3351-8
Zhang, G; Murray, T F; Grandy, D K (1997) Orphanin FQ has an inhibitory effect on the guinea pig ileum and the mouse vas deferens. Brain Res 772:102-6

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