Electroencephalographic techniques, especially event-related electro- encephalographic potentials (ERP), have been used to examine the CNS functioning of individuals at low and high risk for drug dependence. The proposed study will employ these techniques in an examination of 300 non- drug dependent teenagers (aged 16-18) varying in their risk. Three risk factors will be investigated: 1) gender, 2) a family history of either opiate or alcohol dependence, and 3) a personal history of antisocial personality (ASP) characteristics. The ERP battery will include three sets of tasks which putatively challenge frontal brain function. One set of tasks will require rapid changes in strategy, planning, and/or cognitive set. The second task set will manipulate the complexity, speed, or timing of the required motor response. The third will provide measures of ERP activity during the anticipation of avoidable stressors. A fourth task set will evaluate EEG activity at rest and ERPs during """"""""nonfrontal"""""""" tasks. The proposed study will evaluate the hypothesis that subjects at high putative risk for drug dependence (i.e. those with ASP disorder, or a family history of opiate dependence or alcohol dependence) exhibit signs of impaired functioning on tests of cognitive flexibility and motor regulation. In contrast, high risk FH+ or ASP+ subjects are hypothesized to function better than their low risk counterparts on tests of stress avoidance. The validity of these hypotheses will also be evaluated using a battery of more traditional neuropsychological tests.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA008598-05
Application #
2770090
Study Section
Special Emphasis Panel (SRCD)
Project Start
1994-09-30
Project End
2000-08-31
Budget Start
1998-09-01
Budget End
2000-08-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
Bauer, Lance O; Kaplan, Richard F; Hesselbrock, Victor M (2010) P300 and the stroop effect in overweight minority adolescents. Neuropsychobiology 61:180-7
Bauer, Lance O; Hesselbrock, Victor M (2003) Brain maturation and subtypes of conduct disorder: interactive effects on p300 amplitude and topography in male adolescents. J Am Acad Child Adolesc Psychiatry 42:106-15
Bauer, Lance O; Hesselbrock, Victor M (2002) Lateral asymmetries in the frontal brain: effects of depression and a family history of alcoholism in female adolescents. Alcohol Clin Exp Res 26:1662-8
Bauer, Lance O (2002) Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. Drug Alcohol Depend 66:137-45
Bauer, L O (2001) Predicting relapse to alcohol and drug abuse via quantitative electroencephalography. Neuropsychopharmacology 25:332-40
Bauer, L O (2001) CNS recovery from cocaine, cocaine and alcohol, or opioid dependence: a P300 study. Clin Neurophysiol 112:1508-15
Bauer, L O; Hesselbrock, V M (2001) CSD/BEM localization of P300 sources in adolescents ""at-risk"": evidence of frontal cortex dysfunction in conduct disorder. Biol Psychiatry 50:600-8
Bauer, L O; Hesselbrock, V M (1999) P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development. Biol Psychiatry 46:263-72
Wehr, A; Bauer, L O (1999) Verbal ability predicts abstinence from drugs and alcohol in a residential treatment population. Psychol Rep 84:1354-60
Bauer, L O; Hesselbrock, V M (1999) Subtypes of family history and conduct disorder: effects on P300 during the stroop test. Neuropsychopharmacology 21:51-62

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