In a MDA-funded Stage I Behavioral Therapies Development grant (1994- present) that we are now completing, our group has developed a manualized integrated relapse prevention group therapy (""""""""Integrated Group Therapy"""""""") for patients with current comorbid substance dependence and bipolar disorder (BPD). Outcome results for Integrated Group Therapy (IGT) have been promising; patients showed significant improvement in drug use and psychiatric symptoms from baseline to the end of treatment, and from baseline to 3- month post-treatment follow-up. Moreover, in this open, non-randomized pilot study, patients in IGT had significantly fewer days of drug use at the end of treatment and at 3-month post-treatment follow-up than did a comparison group of patients who received no experimental group treatment, but had monthly assessments. The primary aim of our current competing continuation proposal is to extend the work accomplished under this previous award (DA09400) by conducting a randomized. controlled Stage lb study in 60 patients, comparing 20 weekly sessions of Integrated Group Therapy (in which both BPD and substance use disorder are addressed simultaneously) versus an equivalent amount of an active comparison treatment, namely, Group Drug Counseling; the latter treatment focuses exclusively on the patients' substance use disorder, without focusing on BPD. We plan to assess patients monthly and will compare treatment outcomes for IGT versus Group Drug Counseling (GDC) at 5 months (i.e., the end of treatment), 8 months (3-month post-treatment follow-up), and one year (7-month post-treatment follow-up). We hypothesize that patients in IGT will have better outcomes than will patients who receive GDC, as measured by (a) days of drug use and (b) BPD symptoms. We plan to use effect sizes from the proposed study to help us in preparation for a larger-scale subsequent Stage II study.
Our second aim i s to compare the impact of these two treatments on a number of secondary outcome measures, including treatment retention, patient satisfaction, medication compliance, overall functioning, and engagement in HIV risk behaviors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA009400-05
Application #
6137795
Study Section
Special Emphasis Panel (ZDA1-WXG-F (07))
Program Officer
Czechowicz, Dorynne D
Project Start
1994-09-30
Project End
2001-11-30
Budget Start
2000-01-01
Budget End
2000-12-31
Support Year
5
Fiscal Year
2000
Total Cost
$230,792
Indirect Cost
Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478
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Weiss, Roger D; Griffin, Margaret L; Kolodziej, Monika E et al. (2007) A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. Am J Psychiatry 164:100-7
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Weiss, Roger D; Kolodziej, Monika; Griffin, Margaret L et al. (2004) Substance use and perceived symptom improvement among patients with bipolar disorder and substance dependence. J Affect Disord 79:279-83
Weiss, Roger D (2004) Treating patients with bipolar disorder and substance dependence: lessons learned. J Subst Abuse Treat 27:307-12
Greenfield, Shelly F; Sugarman, Dawn E; Muenz, Larry R et al. (2003) The relationship between educational attainment and relapse among alcohol-dependent men and women: a prospective study. Alcohol Clin Exp Res 27:1278-85
Greenfield, Shelly F; Hennessy, Grace; Sugarman, Dawn E et al. (2003) What general psychiatrists ask addiction psychiatrists: a review of 381 substance abuse consultations in a psychiatric hospital. Am J Addict 12:18-28
Greenfield, Shelly F (2002) Women and alcohol use disorders. Harv Rev Psychiatry 10:76-85
Greenfield, Shelly F; Kolodziej, Monika E; Sugarman, Dawn E et al. (2002) History of abuse and drinking outcomes following inpatient alcohol treatment: a prospective study. Drug Alcohol Depend 67:227-34

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