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Yongye, Austin B; Appel, Jon R; Giulianotti, Marc A et al. (2009) Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. Bioorg Med Chem 17:5583-97
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Houghten, Richard A; Pinilla, Clemencia; Giulianotti, Marc A et al. (2008) Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods. J Comb Chem 10:3-19
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Houghten, Richard A; Dooley, Colette T; Appel, Jon R (2006) In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands. AAPS J 8:E371-82
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Hoesl, Cornelia E; Ostresh, John M; Houghten, Richard A et al. (2006) Solid phase synthesis of 3,4,7-trisubstituted 4,5,8,9-tetrahydro-3H-imidazo[1,2-a][1,3,5]triazepin-2(7H)-thiones and N-alkyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-a][1,3,5]triazepin-2-amines. J Comb Chem 8:127-31
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Hensler, Mary E; Bernstein, Gregory; Nizet, Victor et al. (2006) Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug-resistant Gram-positive pathogens identified from a mixture-based combinatorial library. Bioorg Med Chem Lett 16:5073-9
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Nefzi, Adel; Ostresh, John M; Appel, Jon R et al. (2006) Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries. Bioorg Med Chem Lett 16:4331-8
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Nefzi, Adel; Hoesl, Cornelia E; Pinilla, Clemencia et al. (2006) Synthesis of platinum(II) chiral tetraamine coordination complexes. J Comb Chem 8:780-3
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Nefzi, Adel; Santos, Rodegar T (2005) Efficient approaches toward the solid-phase synthesis of new heterocyclic azoniaspiro ring systems: synthesis of tri- and tetrasubstituted 10-oxo- 3,9-diaza-6-azoniaspiro[5.5]undecanes. J Org Chem 70:9622-5
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Hoesl, Cornelia E; Nefzi, Adel; Houghten, Richard A (2004) Halogenoalkyl isocyanates as bifunctional reagents in an Aza-Wittig/heterocyclization reaction on the solid phase: efficient entry into new tetracyclic benzimidazole systems. J Comb Chem 6:220-3
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Nefzi, Adel; Ostresh, John M; Yu, Yongping et al. (2004) Combinatorial chemistry: libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds. J Org Chem 69:3603-9
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