Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA009487-03
Application #
2013311
Study Section
Special Emphasis Panel (SRCD)
Project Start
1994-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1998-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Neurology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
McCann, Una D; Szabo, Zsolt; Vranesic, Melin et al. (2008) Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine (""ecstasy"") users: relationship to cognitive performance. Psychopharmacology (Berl) 200:439-50
McCann, Una D; Kuwabara, Hiroto; Kumar, Anil et al. (2008) Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users. Synapse 62:91-100
Ricaurte, George A; McCann, Una D (2005) Recognition and management of complications of new recreational drug use. Lancet 365:2137-45
Xie, Tao; Tong, Liqiong; McCann, Una D et al. (2004) Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons. J Neurosci 24:7043-50
McCann, Una D; Ricaurte, George A (2004) Amphetamine neurotoxicity: accomplishments and remaining challenges. Neurosci Biobehav Rev 27:821-6
Yuan, Jie; Cord, Branden J; McCann, Una D et al. (2002) Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity. J Neurochem 80:960-9
Reneman, Liesbeth; Booij, Jan; Habraken, Jan B A et al. (2002) Validity of [123I]beta-CIT SPECT in detecting MDMA-induced serotonergic neurotoxicity. Synapse 46:199-205
Hatzidimitriou, George; Tsai, Elizabeth H; McCann, Una D et al. (2002) Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine. Synapse 44:51-7
Ricaurte, George A; Yuan, Jie; Hatzidimitriou, George et al. (2002) Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA (""ecstasy""). Science 297:2260-3
Xie, Tao; Tong, Liqiong; Barrett, Tanya et al. (2002) Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicity. J Neurosci 22:274-83

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