|
Musachio, John L; Hong, Jinsoo; Ichise, Masanori et al. (2006) Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorg Med Chem Lett 16:3101-4
|
|
Iso, Yasuyoshi; Grajkowska, Ewa; Wroblewski, Jarda T et al. (2006) Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. J Med Chem 49:1080-100
|
|
Kozikowski, Alan P; Zhao, Lianyun; Zhang, Ao et al. (2006) Structural remodeling of cocaine: design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors. ChemMedChem 1:58-65
|
|
Wee, Sunmee; Wang, Zhixia; He, Rong et al. (2006) Role of the increased noradrenergic neurotransmission in drug self-administration. Drug Alcohol Depend 82:151-7
|
|
Zhou, Jia; Klass, Thomas; Johnson, Kenneth M et al. (2005) Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants. Bioorg Med Chem Lett 15:2461-5
|
|
He, Rong; Kurome, Toru; Giberson, Kelly M et al. (2005) Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhi J Med Chem 48:7970-9
|
|
Ukairo, Okechukwu T; Bondi, Corry D; Newman, Amy Hauck et al. (2005) Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. J Pharmacol Exp Ther 314:575-83
|
|
Petukhov, Pavel A; Zhang, Jianrong; Wang, Cheng Z et al. (2004) Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring. J Med Chem 47:3009-18
|
|
Zhou, Jia; He, Rong; Johnson, Kenneth M et al. (2004) Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. J Med Chem 47:5821-4
|
|
Zhou, Jia; Zhang, Ao; Klass, Thomas et al. (2003) Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: synthesis and evaluation of their uptake inhibition at monoamine transporter sites. J Med Chem 46:1997-2007
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