The primary purpose of this project is to apply basic research in cognition and affect to the assessment of smoking craving. Smoking craving is conceptualized as the activation of a set of interrelated response systems that increase disposition for smoking. Smoking deprivation, perceived opportunity to smoke, and individual differences in smoking patterns are predicted to produce craving states involving specific configurations of affective, cognitive, self-report, and behavioral responding. Investigation of these processes proceeds from observable methods and measures developed within experimental psychology. Each response modality is posited to be linked conceptually to addiction with stronger responses facilitating drug use. Moreover, the pattern and type of responses are expected to vary as a function of specific craving states. The investigators will use an established cue exposure procedure to test their aims. Heavy smokers and nondependent tobacco chippers will be exposed to smoking and control cues during nicotine-deprived or nondeprived states. Subjects either will or will not anticipate being able to smoke during the study. Study 1 (N=288) will test whether individual differences (type of smoker), and situational differences (e.g., perceived smoking opportunity, deprivation state) produce several distinct types of craving. Study 2 (N=144) will test aspects of the proposed craving model during alcohol (.82 g/kg males, .74/kg females) or placebo consumption in smokers and tobacco chippers. Alcohol is a robust manipulation that is of both conceptual and clinical importance for cigarette craving. This research is expected to advance knowledge of both situational and individual variables affecting the nature of craving. By tying craving to observable responses that are meaningfully linked to smoking, the proposed experiments aim to increase our knowledge of affective and cognitive processes in addiction. This research will test whether there are several types of craving, distinguished by the pattern of responses. Regardless of the outcome, the research will provide critical data regarding observable effects of cue exposure and nicotine deprivation manipulations on smokers, which will increase understanding of factors contributing to the etiology, maintenance, and treatment of nicotine addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA010605-03
Application #
2749159
Study Section
Special Emphasis Panel (SRCD)
Program Officer
Schnur, Paul
Project Start
1996-09-01
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Sayers, W Michael; Sayette, Michael A (2013) Suppression on your own terms: internally generated displays of craving suppression predict rebound effects. Psychol Sci 24:1740-6
Sayette, Michael A; Tiffany, Stephen T (2013) Peak provoked craving: an alternative to smoking cue-reactivity. Addiction 108:1019-25
O'Connell, Kathleen A; Shiffman, Saul; Decarlo, Lawrence T (2011) Does extinction of responses to cigarette cues occur during smoking cessation? Addiction 106:410-7
Sayette, Michael A; Griffin, Kasey M; Sayers, W Michael (2010) Counterbalancing in smoking cue research: a critical analysis. Nicotine Tob Res 12:1068-79
Sayette, Michael A; Schooler, Jonathan W; Reichle, Erik D (2010) Out for a smoke: the impact of cigarette craving on zoning out during reading. Psychol Sci 21:26-30
O'Connell, Kathleen A; Schwartz, Joseph E; Shiffman, Saul (2008) Do resisted temptations during smoking cessation deplete or augment self-control resources? Psychol Addict Behav 22:486-95
Sayette, Michael A; Loewenstein, George; Griffin, Kasey M et al. (2008) Exploring the cold-to-hot empathy gap in smokers. Psychol Sci 19:926-32
Wilson, Stephen J; Sayette, Michael A; Delgado, Mauricio R et al. (2008) Effect of smoking opportunity on responses to monetary gain and loss in the caudate nucleus. J Abnorm Psychol 117:428-34
Donny, Eric C; Griffin, Kasey M; Shiffman, Saul et al. (2008) The relationship between cigarette use, nicotine dependence, and craving in laboratory volunteers. Nicotine Tob Res 10:934-42
Griffin, Kasey M; Sayette, Michael A (2008) Facial reactions to smoking cues relate to ambivalence about smoking. Psychol Addict Behav 22:551-6

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