The study's first aim is to investigate the development of regular and problem substance use and abuse among youth in the context of other problem behaviors, including delinquency, mental health problems, and high risk sexual behaviors.
The second aims i s to investigate the development of these problem behaviors as a function of risk and protective factors. The study sample consists of 503 African-American and Caucasian boys in the youngest sample of the Pittsburgh Youth Study, who were first studied at ages 6-7, and who have been followed up over 13 assessments over the past nine years without interruption (up to ages 15- 16). The present proposal extends this follow-up with five yearly assessments until age 20. Since substance use, delinquency, mental health problems, and high risk sexual behaviors tend to become more serious during late adolescence, the study will be able to throw light on the relationships between the four problem domains in order to account for multi-problem youth that emerge during that period. Four developmental types of substance abuse are proposed and will be tested, an Early Onset Mixed Type, a Late Onset Delinquent Type, an Internalizing Type, and a Nondeviant History Type. The study is strengthened by the fact that risk and protective factors have already been measured over 12 data waves (in such domains as individual, family, peer, school, and neighborhood) and, together with the planned five data waves, will offer an unique opportunity to explain substance abuse and its co-occurring problems. In addition, the study is enriched by the collection of psychiatric diagnosis at age 7, 15, 18, 20 (with substance abuse and dependence diagnoses measured at all five proposed assessments), and biological data collected at age 15-16, which will allow an examination of the interaction between biological and social factors in the explanation of substance abuse and associated problems.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA011018-05
Application #
6378677
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Conway, Kevin P
Project Start
1997-04-01
Project End
2004-03-31
Budget Start
2001-04-01
Budget End
2004-03-31
Support Year
5
Fiscal Year
2001
Total Cost
$506,049
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Byrd, Amy L; Hawes, Samuel W; Loeber, Rolf et al. (2016) Interpersonal Callousness from Childhood to Adolescence: Developmental Trajectories and Early Risk Factors. J Clin Child Adolesc Psychol :1-16
White, Helene R; Bechtold, Jordan; Loeber, Rolf et al. (2015) Divergent marijuana trajectories among men: Socioeconomic, relationship, and life satisfaction outcomes in the mid-30s. Drug Alcohol Depend 156:62-69
Byrd, Amy L; Loeber, Rolf; Pardini, Dustin A (2014) Antisocial behavior, psychopathic features and abnormalities in reward and punishment processing in youth. Clin Child Fam Psychol Rev 17:125-56
Gordon, Rachel A; Rowe, Hillary L; Pardini, Dustin et al. (2014) Serious Delinquency and Gang Participation: Combining and Specializing in Drug Selling, Theft and Violence. J Res Adolesc 24:235-251
Pardini, Dustin A; Raine, Adrian; Erickson, Kirk et al. (2014) Lower amygdala volume in men is associated with childhood aggression, early psychopathic traits, and future violence. Biol Psychiatry 75:73-80
Byrd, Amy L; Kahn, Rachel E; Pardini, Dustin A (2013) A Validation of the Inventory of Callous-Unemotional Traits in a Community Sample of Young Adult Males. J Psychopathol Behav Assess 35:
White, Helene Raskin; Fite, Paula; Pardini, Dustin et al. (2013) Moderators of the dynamic link between alcohol use and aggressive behavior among adolescent males. J Abnorm Child Psychol 41:211-22
Cerdá, Magdalena; Bordelois, Paula M; Keyes, Katherine M et al. (2013) Cumulative and recent psychiatric symptoms as predictors of substance use onset: does timing matter? Addiction 108:2119-28
Lee, Chioun; White, Helene R (2012) Effects of childhood maltreatment on violent injuries and premature death during young adulthood among urban high-risk men. Arch Pediatr Adolesc Med 166:814-20
Keijsers, Loes; Loeber, Rolf; Branje, Susan et al. (2012) Parent-child relationships of boys in different offending trajectories: a developmental perspective. J Child Psychol Psychiatry 53:1222-32

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