The increasing use of A/M and the consequences of its use continue to generate social and governmental concern, which has been manifested in increased public attention and initiatives to improve interdiction, prevention, and treatment strategies, with a priority placed on research efforts to inform these strategies. The proposed continuation will conduct further research on a diverse sample of treated and untreated A/M users to provide an empirical basis for the improvement of prevention and treatment strategies now being developed. The continuation will extend the research by administering a follow-up Natural History Interview (NIH) to the current study's sample of 400 randomly sampled individuals admitted to treatment for A/M use in 1995-97 to publicly funded outpatient and residential programs in Los Angeles County. The continuation will expand the research to interview (using the same NHI) a sample of users who have never been in treatment in order to better understand the untreated course of A/M use and barriers to treatment entry. Two broad primary aims will be addressed: (1) Assess AIM use patterns over time and determine the long-term consequences of A/M use, including the conditional impact of demographic, background, and health characteristics, and the relationships of A/M use histories to other substance use, HIV/AIDS risk behaviors, and criminal behaviors. A/M use histories and related characteristics will be compared between the treated and untreated groups. (2) Examine long-term treatment outcomes (including differential effects for ethnicity, gender, modality, and other user characteristics) and patterns of treatment utilization for A/M users. Motivation, addiction severity, and other barriers limiting treatment access for the never-treated sample will also be described. Multivariate analyses including generalized models for repeated measures, survival analysis, logistic regression, structural equation modeling, and growth modeling, as well as ethnographic methods, will be used to address these aims. New data from the proposed continuation will allow analysis of longer A/M use histories and assessment of long-term treatment outcomes (not yet studied for AIM users). Findings will serve to improve strategies for treatment outreach, engagement, service delivery, and retention, and to design risk reduction programs exterior to the treatment system.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA011020-06
Application #
6628340
Study Section
Special Emphasis Panel (ZRG1-SNEM-2 (01))
Program Officer
Cartwright, William S
Project Start
1998-02-15
Project End
2005-07-31
Budget Start
2003-02-01
Budget End
2005-07-31
Support Year
6
Fiscal Year
2003
Total Cost
$511,615
Indirect Cost
Name
University of California Los Angeles
Department
Type
Other Domestic Higher Education
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Brecht, Mary-Lynn; Herbeck, Diane M (2014) Pregnancy and fetal loss reported by methamphetamine-using women. Subst Abuse 8:25-33
Brecht, Mary-Lynn; Herbeck, Diane (2014) Time to relapse following treatment for methamphetamine use: a long-term perspective on patterns and predictors. Drug Alcohol Depend 139:18-25
Brecht, Mary-Lynn; Lovinger, Katherine; Herbeck, Diane M et al. (2013) Patterns of treatment utilization and methamphetamine use during first 10 years after methamphetamine initiation. J Subst Abuse Treat 44:548-56
Herbeck, Diane M; Brecht, Mary-Lynn; Pham, Aurora Z (2013) Racial/ethnic differences in health status and morbidity among adults who use methamphetamine. Psychol Health Med 18:262-74
Brecht, Mary-Lynn; Herbeck, Diane (2013) Methamphetamine Use and Violent Behavior: User Perceptions and Predictors. J Drug Issues 43:468-482
Bolanos, Franklin; Herbeck, Diane; Christou, Dayna et al. (2012) Using facebook to maximize follow-up response rates in a longitudinal study of adults who use methamphetamine. Subst Abuse 6:1-11
Brecht, Mary-Lynn; Huang, David; Evans, Elizabeth et al. (2008) Polydrug use and implications for longitudinal research: ten-year trajectories for heroin, cocaine, and methamphetamine users. Drug Alcohol Depend 96:193-201
Brecht, Mary-Lynn; Greenwell, Lisa; Anglin, M Douglas (2007) Substance use pathways to methamphetamine use among treated users. Addict Behav 32:24-38
Brecht, Mary-Lynn; Greenwell, Lisa; von Mayrhauser, Christina et al. (2006) Two-year outcomes of treatment for methamphetamine use. J Psychoactive Drugs Suppl 3:415-26
Brecht, Mary-Lynn; Anglin, M Douglas; Dylan, Michelle (2005) Coerced treatment for methamphetamine abuse: differential patient characteristics and outcomes. Am J Drug Alcohol Abuse 31:337-56

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