The goal of this research application is to develop electrophysiological measures for evaluating the central nervous system (CNS) as it is affected by marihuana. This goal will be pursued by assaying young adults who only occasionally ( 1/month) or chronically ( 3/week) smoke marihuana (low- vs. high-risk subjects), with equal and sufficiently large numbers of both male and female subjects employed for all comparisons. Electroencephalographic (EEG) and event-related brain potential (ERP) paradigms that are sensitive to attention and memory processes will be performed by each subject before and after smoking a placebo or marihuana cigarette on two independent occasions. This approach will optimize CNS electrophysiological differences between occasional (low-risk) and chronic (high-risk) adult marihuana users and produce for the first time a comprehensive assessment of marihuana's effect on CNS function. Because both male and female subjects will be employed in each assessment condition, reliable information on gender differences for marihuana's short- and long-term influence also will be acquired. The most sensitive and effective paradigms will provide reliable neuroelectric signatures that reflect marihuana's cognitive effects.
| Polich, John; Criado, Jose R (2006) Neuropsychology and neuropharmacology of P3a and P3b. Int J Psychophysiol 60:172-85 |
| Hagen, Galen F; Gatherwright, James R; Lopez, Brian A et al. (2006) P3a from visual stimuli: task difficulty effects. Int J Psychophysiol 59:8-14 |
| Polich, John (2004) Clinical application of the P300 event-related brain potential. Phys Med Rehabil Clin N Am 15:133-61 |
| Jeon, Yang-Whan; Polich, John (2003) Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications. Psychophysiology 40:684-701 |
| Gonsalvez, Craig L; Polich, John (2002) P300 amplitude is determined by target-to-target interval. Psychophysiology 39:388-96 |
| Demiralp, Tamer; Ucok, Alp; Devrim, Muge et al. (2002) N2 and P3 components of event-related potential in first-episode schizophrenic patients: scalp topography, medication, and latency effects. Psychiatry Res 111:167-79 |
| Yordanova, J; Kolev, V; Polich, J (2001) P300 and alpha event-related desynchronization (ERD). Psychophysiology 38:143-52 |
| Jeon, Y W; Polich, J (2001) P3a from a passive visual stimulus task. Clin Neurophysiol 112:2202-8 |
| Jeon, Y W; Polich, J (2001) P300 asymmetry in schizophrenia: a meta-analysis. Psychiatry Res 104:61-74 |
| Polich, J; Herbst, K L (2000) P300 as a clinical assay: rationale, evaluation, and findings. Int J Psychophysiol 38:19-Mar |
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