This proposal seeks support for a ten-year follow-up of the 5877 people who participated in Parts I and II of the National Comorbidity Survey (NCS; Kessler et al., 1994), a nationally representative survey of people in the age range 15-54 in the U.S. household population designed to estimate the prevalences and correlates of DSM-III-R mental and substance disorders. The focus of the follow-up survey will be on the relationship between temporally primary mental disorders and the subsequent onset and course of substance disorders. Specifically, we aim to use information about mental disorders collected in the baseline survey to predict the subsequent onset of substance use and the onset and course of substance disorders over the intervening decade. We also aim to use causal modeling to evaluate the effects of mediators and modifiers of these associations. There are two specific aims. The first is to evaluate the two overarching hypotheses that guide the proposed research: that temporally primary mental disorders assessed at baseline predict the subsequent first onset and progression of substance use and substance disorders over the intervening decade; and that co-occurring mental disorders among baseline respondents with substance disorders are significant predictors of continuation over the intervening decade. The second specific aim is to carry out more refined analyses to elucidate the mechanisms involved in the associations documented under the first aim. A large number of potentially important mediators and modifiers will be considered here, with a particular interest in modifiable risk factors that could be intervention targets associated with mental disorders. All of the work under this second aim will separately consider the subsample of respondents with primary conduct disorder and the subsample of respondents without conduct disorder who have primary anxiety-mood disorders. The processes involved in the onset and course of secondary substance disorders are anticipated to be considerably different in these two subsamples, with substance disorders strongly related to a broader pattern of unconventionality and risk taking in the subsample with primary conduct disorder and to self- medication in the subsample with primary anxiety-mood disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA012058-03
Application #
6378812
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Conway, Kevin P
Project Start
1999-07-15
Project End
2004-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
3
Fiscal Year
2001
Total Cost
$1,810,992
Indirect Cost
Name
Harvard University
Department
Administration
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Mojtabai, Ramin; Stuart, Elizabeth A; Hwang, Irving et al. (2017) Long-term effects of mental disorders on marital outcomes in the National Comorbidity Survey ten-year follow-up. Soc Psychiatry Psychiatr Epidemiol 52:1217-1226
Kessler, R C; van Loo, H M; Wardenaar, K J et al. (2017) Using patient self-reports to study heterogeneity of treatment effects in major depressive disorder. Epidemiol Psychiatr Sci 26:22-36
Byers, Amy L; Lai, Amy X; Nelson, Craig et al. (2017) Predictors of Mental Health Services Use Across the Life Course among Racially-Ethnically Diverse Adults. Am J Geriatr Psychiatry 25:1213-1222
Beristianos, Matthew H; Maguen, Shira; Neylan, Thomas C et al. (2016) Trauma Exposure and Risk of Suicidal Ideation Among Older Adults. Am J Geriatr Psychiatry 24:639-643
Byers, Amy L; Lai, Amy X; Arean, Patricia et al. (2016) Mental Health Service Use Across the Life Course Among Adults With Psychiatric Disorders and Prior Suicidal Behavior. Psychiatr Serv 67:452-5
Beristianos, Matthew H; Maguen, Shira; Neylan, Thomas C et al. (2016) TRAUMA EXPOSURE AND RISK OF SUICIDAL IDEATION AMONG ETHNICALLY DIVERSE ADULTS. Depress Anxiety 33:495-501
Kessler, R C; van Loo, H M; Wardenaar, K J et al. (2016) Testing a machine-learning algorithm to predict the persistence and severity of major depressive disorder from baseline self-reports. Mol Psychiatry 21:1366-71
Tegethoff, Marion; Belardi, Angelo; Stalujanis, Esther et al. (2015) Association between mental disorders and physical diseases in adolescents from a nationally representative cohort. Psychosom Med 77:319-32
Tegethoff, Marion; Belardi, Angelo; Stalujanis, Esther et al. (2015) Comorbidity of Mental Disorders and Chronic Pain: Chronology of Onset in Adolescents of a National Representative Cohort. J Pain 16:1054-64
Mojtabai, Ramin; Stuart, Elizabeth A; Hwang, Irving et al. (2015) Long-term effects of mental disorders on educational attainment in the National Comorbidity Survey ten-year follow-up. Soc Psychiatry Psychiatr Epidemiol 50:1577-91

Showing the most recent 10 out of 27 publications