This work will facilitate more effective drug abuse prevention and treatment efforts on a societal level by enhancing the accuracy of drug abuse measurement. Specifically, this study will provide definitive answers regarding the viability of incorporating biological measurement of drug use in the context of general population household surveys on drug abuse. The proposed study will evaluate the feasibility and utility of three different types of biological measurement procedures (hair, saliva, and urine testing) to be used as an adjunct to a household survey on drug abuse. This study will compare the relative acceptability of the different biological test methods among survey participants through household surveys of 600 randomly selected subjects residing in the City of Chicago. By randomly assigning subjects to either a high or low incentive drug test condition, this study will evaluate the role of alternative incentive strategies on participation in biological measurement. Through quantitative and qualitative analyses, this study will assess the myriad of subject, interview condition, and procedural variables associated with drug test participation in household surveys. This study will examine impact of prior exposure to drug testing and perceptions about drug testing accuracy on willingness to participate in biological measurement. The study will also gain an understanding of adult willingness to provide consent for similar drug testing in children. Alternative statistical procedures for constructing prevalence estimators from multiple biological measures will be explored. Results derived from biological assessments will be compared with responses to questions about drug use provided in an Audio Computer Assisted Self Interview that precedes the biological assessment. Taking into account factors influencing drug test participation, these comparisons will be used to evaluate the extent of underreporting of drug use in the general population. Subject and drug use variables associated with drug use underreporting will be fully analyzed. The utility of hair testing will be further evaluated by examining whether a new confirmation process (negative ion screening) yields increased sensitivity for detecting marijuana metabolites.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Study Section
Special Emphasis Panel (ZRG1 (01))
Program Officer
Thomas, Yonette
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University of Illinois at Chicago
Schools of Medicine
United States
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Mackesy-Amiti, Mary Ellen; Fendrich, Michael; Johnson, Timothy P (2009) Substance-related problems and treatment among men who have sex with men in comparison to other men in Chicago. J Subst Abuse Treat 36:227-33
Fendrich, Michael; Mackesy-Amiti, Mary Ellen; Johnson, Timothy P (2008) Validity of self-reported substance use in men who have sex with men: comparisons with a general population sample. Ann Epidemiol 18:752-9
Lippert, Adam M; Fendrich, Michael; Johnson, Timothy P (2008) Vicarious exposure to terrorist attacks and substance use: results from an urban household survey. J Urban Health 85:411-27
Johnson, Timothy P; Fendrich, Michael (2007) Homelessness and drug use: evidence from a community sample. Am J Prev Med 32:S211-8
Johnson, Timothy; Fendrich, Michael (2005) Modeling sources of self-report bias in a survey of drug use epidemiology. Ann Epidemiol 15:381-9
Fendrich, Michael; Mackesy-Amiti, Mary Ellen; Johnson, Timothy P et al. (2005) Tobacco-reporting validity in an epidemiological drug-use survey. Addict Behav 30:175-81
Fendrich, Michael; Johnson, Timothy P (2005) Race/ethnicity differences in the validity of self-reported drug use: results from a household survey. J Urban Health 82:iii67-81
Fendrich, Michael; Johnson, Timothy P; Wislar, Joseph S et al. (2004) The utility of drug testing in epidemiological research: results from a general population survey. Addiction 99:197-208
Fendrich, Michael; Johnson, Timothy P; Wislar, Joseph S et al. (2004) Drug test feasibility in a general population household survey. Drug Alcohol Depend 73:237-50
Fendrich, Michael; Rosenbaum, Dennis P (2003) Recanting of substance use reports in a longitudinal prevention study. Drug Alcohol Depend 70:241-53

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