This revised renewal application seeks to extend the study of developmental trajectories of drug use and related outcomes, and to examine the effects of genetic and non-genetic factors on these trajectories, of highly informative groups of youth by conducting wave 5 and 6 assessments (representing years 10 and 12 in the longitudinal study) on three youth cohorts. This effort will continue our prospective investigation into young adulthood of the developmental pathways of drug use behaviors, including SUDs. One cohort (high-risk; n = 274; mean age in 2007 = 20.4) is at elevated risk to develop SUDs as indexed by a history of externalizing disorders (e.g., ADHD, subclinical-ADHD, ODD, and CD); the second cohort (treatment; n = 393; mean age in 2007 = 20.6) has already displayed an early onset of SUDs and also has history of externalizing disorders. A third, matched control sample (n = 190; mean age in 2007 = 20.5) is also included in the design. ? ? The study will address five specific aims: (1) collect at wave 5 and wave 6 developmentally appropriate outcome measures that reflect a) developmental trajectories of drug use behaviors, and b) developmental patterns of psychosocial functioning; (2) collect DNA samples from study participants at wave 5 and genotype a selected panel of single nucleotide polymorphisms (SNPs) and variable number tandem repeats (VNTRs) in candidate genes that are potentially associated with drug-related phenotypes; (3) investigate the relations between non-genetic factors and (a) developmental trajectories of drug use (e.g., slopes and trajectory classes of drug use and SUDs), and (b) developmental trajectories of psychosocial functioning (e.g., slopes and trajectory classes of functioning); (4) investigate the relations between genetic polymorphisms and (a) developmental trajectories of drug use (e.g., slopes and trajectory classes of drug use and SUDs), and (b) developmental trajectories of psychosocial functioning (e.g., slopes and trajectory classes of functioning); and (5) test a comprehensive model of predicting drug use and psychosocial functioning trajectories to determine the relationships of genetic with non-genetic factors and how these variables may contribute to different trajectory patterns.Project Narrative ? ? A greater understanding of the course of adolescent and young adult drug use behaviors and level of functioning can meaningfully inform prevention and treatment approaches. Also, the addition of genetic variables further strengthens our search for underlying factors that contribute to variability in developmental pathways. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA012995-07
Application #
7502063
Study Section
Psychosocial Development, Risk and Prevention Study Section (PDRP)
Program Officer
Weinberg, Naimah Z
Project Start
2000-02-15
Project End
2012-08-31
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
7
Fiscal Year
2008
Total Cost
$534,697
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychiatry
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Boghossian, Nansi S; Sicko, Robert J; Kay, Denise M et al. (2016) Rare copy number variants implicated in posterior urethral valves. Am J Med Genet A 170:622-33
Samek, Diana R; Bailey, Jennifer; Hill, Karl G et al. (2016) A Test-Replicate Approach to Candidate Gene Research on Addiction and Externalizing Disorders: A Collaboration Across Five Longitudinal Studies. Behav Genet 46:608-626
Symmes, Amanda; Winters, Ken C; Fahnhorst, Tamara et al. (2015) The Association Between Attention-Deficit Hyperactivity Disorder and Nicotine Use Among Adolescents and Young Adults. J Child Adolesc Subst Abuse 24:37-45
Breyer, Jessie L; Lee, Susanne; Winters, Ken C et al. (2014) A longitudinal study of childhood ADHD and substance dependence disorders in early adulthood. Psychol Addict Behav 28:238-46
Winters, Ken C (2013) Advances in the science of adolescent drug involvement: implications for assessment and diagnosis - experience from the United States. Curr Opin Psychiatry 26:318-24
Kaminer, Yifrah; Winters, Ken C (2012) Proposed DSM-5 substance use disorders for adolescents: if you build it, will they come? Am J Addict 21:280-1; author reply 282
Winters, Ken C; Arria, Amelia (2011) Adolescent Brain Development and Drugs. Prev Res 18:21-24
Winters, Ken C; Lee, Susanne; Botzet, Andria et al. (2011) A Prospective Examination of the Association of Stimulant Medication History and Drug Use Outcomes among Community Samples of ADHD Youths. J Child Adolesc Subst Abuse 20:314-329
Gans, Jeremy; Falco, Mathea; Schackman, Bruce R et al. (2010) An In-Depth Survey of the Screening and Assessment Practices of Highly Regarded Adolescent Substance Abuse Treatment Programs. J Child Adolesc Subst Abuse 19:33-47
Lee, Chih-Yuan S; Winters, Ken C; Wall, Melanie M (2010) Trajectories of Substance Use Disorders in Youth: Identifying and Predicting Group Memberships. J Child Adolesc Subst Abuse 19:135-157

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