In the context of a prospective study of recent injection drug users (IDUs) and a survey of non-injection cocaine and heroin users (NICHUs), we propose to address three major questions about hepatitis C (HCV) infection: 1) is indirect sharing (e.g., sharing cotton, cookers) a risk for incident HCV in IDUs, 2) is sharing implements for smoking/snorting drugs (e.g., straws) associated with HCV in NICHUs, and 3) because HCV clearance in uncommon (sic), what viral/host factors are associated with clearance? To address these questions, we will recruit 450 new IDUs (> 15 years old, < 1 injecting) and 200 NICHUs using outreach techniques. At baseline we will perform HCV, HIV and hepatitis B (HBV) serology and ascertain risk behaviors using audio computer assisted self-interview (ACASI); correlates of infection will be analyzed using logistic regression. IDUs will be followed at 2 month intervals with venipuncture to identify incident cases of HCV (using antibody test and HCV-PCR) and risk behaviors obtained using ACASI. In analyses, after behaviors are considered separately, a risk profile will be developed using Multiple Ordinate Risk techniques: risk factors for HCV infection will use survival methods. Clearance of HCV will be determined by HCV-PCR. Testing by viral sequence analyses and host genetic markers will be done on all new cases of HCV and comparisons between persons with persistent HCV infection and those who have cleared the virus will be done. Because HCV infection usually precedes HCV and HIV infection in IDUs study risk of infection among IDUs when they first begin to inject will provide direction for community workers to target this vulnerable population early. Additionally, this study will provide critical information in two areas that NIH Consensus Development Statement on Management of Hepatitis C identified as needing further research: 1) modes of transmission of HCV among substance abusers and 2) reasons for lack of HCV clearance.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA013146-05
Application #
6723812
Study Section
Special Emphasis Panel (ZRG1-AARR-6 (01))
Program Officer
Lambert, Elizabeth
Project Start
2000-03-10
Project End
2006-02-28
Budget Start
2004-04-09
Budget End
2006-02-28
Support Year
5
Fiscal Year
2004
Total Cost
$649,584
Indirect Cost
Name
New York Academy of Medicine
Department
Type
DUNS #
075239632
City
New York
State
NY
Country
United States
Zip Code
10029
Ompad, Danielle C; Friedman, Samuel R; Hwahng, Sel J et al. (2011) HIV risk behaviors among young drug using women who have sex with women (WSWs) in New York City. Subst Use Misuse 46:274-84
Crawford, Natalie D; Vlahov, David (2010) Progress in HIV reduction and prevention among injection and noninjection drug users. J Acquir Immune Defic Syndr 55 Suppl 2:S84-7
Amesty, S; Ompad, D C; Galea, S et al. (2008) Prevalence and correlates of previous hepatitis B vaccination and infection among young drug-users in New York City. J Community Health 33:139-48
Beard, John R; Tracy, Melissa; Vlahov, David et al. (2008) Trajectory and socioeconomic predictors of depression in a prospective study of residents of New York City. Ann Epidemiol 18:235-43
Galea, Sandro; Ahern, Jennifer; Tracy, Melissa et al. (2008) Longitudinal determinants of posttraumatic stress in a population-based cohort study. Epidemiology 19:47-54
Ompad, Danielle C; Fuller, Crystal M; Chan, Christina A et al. (2008) Correlates of illicit methadone use in New York City: a cross-sectional study. BMC Public Health 8:375
Cerda, Magdalena; Vlahov, David; Tracy, Melissa et al. (2008) Alcohol use trajectories among adults in an urban area after a disaster: evidence from a population-based cohort study. Addiction 103:1296-307
Bonanno, George A; Galea, Sandro; Bucciarelli, Angela et al. (2007) What predicts psychological resilience after disaster? The role of demographics, resources, and life stress. J Consult Clin Psychol 75:671-82
Galea, Sandro; Ahern, Jennifer; Tracy, Melissa et al. (2007) Neighborhood income and income distribution and the use of cigarettes, alcohol, and marijuana. Am J Prev Med 32:S195-202
Fuller, Crystal M; Galea, Sandro; Caceres, Wendy et al. (2007) Multilevel community-based intervention to increase access to sterile syringes among injection drug users through pharmacy sales in New York City. Am J Public Health 97:117-24

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