There is a high prevalence (60-88 percent) of cigarette smoking among people with schizophrenia, but few smoking cessation interventions have been developed for these patients. Little is known about factors that control smoking in this population or whether interventions that reduce cigarette smoking among the general population are effective in smokers with schizophrenia. Two pharmacotherapies that reduce smoking in the general population are transdermal nicotine and sustained release bupropion. Because of neurochemical dysfunction associated with schizophrenia, these pharmacotherapies may be less effective in smokers with schizophrenia. Clinical and experimental studies on the effects of nicotine replacement in smokers with schizophrenia have yielded equivocal results. Preliminary results from a single treatment study with sustained release bupropion appear promising. The studies in the present proposal are designed to examine under controlled laboratory conditions the effects of transdermal nicotine (0, 21, 42 mg/day) and sustained release bupropion (0, 150, 300 mg/day) on smoking in people with schizophrenia and non-schizophrenic controls. The effects of transdermal nicotine and sustained release bupropion on smoking topography measures, smoking urges, nicotine withdrawal symptoms and affect will be determined. These studies use within-subjects, repeated measures, placebo controlled designs. Together, they will provide much-needed information on the biological, behavioral and subjective effects of transdermal nicotine and sustained release bupropion on smoking in people with schizophrenia. In turn, this information could contribute to the development of effective smoking cessation treatments for smokers with schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA014002-04
Application #
6784508
Study Section
Special Emphasis Panel (ZDA1-MXG-S (16))
Program Officer
Montoya, Ivan
Project Start
2001-09-27
Project End
2006-05-31
Budget Start
2004-08-01
Budget End
2006-05-31
Support Year
4
Fiscal Year
2004
Total Cost
$235,500
Indirect Cost
Name
Brown University
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Tidey, Jennifer W; Cassidy, Rachel N; Miller, Mollie E (2016) Smoking Topography Characteristics of Very Low Nicotine Content Cigarettes, With and Without Nicotine Replacement, in Smokers With Schizophrenia and Controls. Nicotine Tob Res 18:1807-12
AhnAllen, Christopher G; Bidwell, L Cinnamon; Tidey, Jennifer W (2015) Cognitive effects of very low nicotine content cigarettes, with and without nicotine replacement, in smokers with schizophrenia and controls. Nicotine Tob Res 17:510-4
Tidey, Jennifer W; Rohsenow, Damaris J; Kaplan, Gary B et al. (2013) Separate and combined effects of very low nicotine cigarettes and nicotine replacement in smokers with schizophrenia and controls. Nicotine Tob Res 15:121-9
Ahnallen, Christopher G; Tidey, Jennifer W (2011) Personalized smoking environment cue reactivity in smokers with schizophrenia and controls: a pilot study. Psychiatry Res 188:286-8
MacKillop, James; Tidey, Jennifer W (2011) Cigarette demand and delayed reward discounting in nicotine-dependent individuals with schizophrenia and controls: an initial study. Psychopharmacology (Berl) 216:91-9
Murphy, James G; MacKillop, James; Tidey, Jennifer W et al. (2011) Validity of a demand curve measure of nicotine reinforcement with adolescent smokers. Drug Alcohol Depend 113:207-14
Tidey, Jennifer W; Rohsenow, Damaris J (2009) Intention to quit moderates the effect of bupropion on smoking urge. Nicotine Tob Res 11:308-12
Tidey, Jennifer W; Rohsenow, Damaris J (2009) Smoking expectancies and intention to quit in smokers with schizophrenia, schizoaffective disorder and non-psychiatric controls. Schizophr Res 115:310-6
Adolfo, Amy B; AhnAllen, Christopher G; Tidey, Jennifer W (2009) Effects of smoking cues on caffeine urges in heavy smokers and caffeine consumers with and without schizophrenia. Schizophr Res 107:192-7
Tidey, Jennifer W; Rohsenow, Damaris J; Kaplan, Gary B et al. (2008) Effects of smoking abstinence, smoking cues and nicotine replacement in smokers with schizophrenia and controls. Nicotine Tob Res 10:1047-56

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