Cocaine abuse continues to be a substantial medical and social problem in the USA and elsewhere. Despite increasing knowledge of the pharmacological basis of cocaine's effects and of the environmental and socio- economic factors in drug abuse, relatively little attention has been given to the cognitive factors that are involved in addiction. It is proposed that a substantial cognitive component of human addiction is a dysexecutive loss of control, that is, an inability to control one's own behavior in light of the strong motivation to consume drug. Our previous research has identified specific executive processes and their corresponding functional neuroanatomy that are compromised in cocaine users. Specifically, anterior cingulate and right dorsolateral prefrontal hypoactivity have been observed for response inhibition and error detection tasks in active cocaine users. As these structures are central to the cognitive control of behavior, their dysregulation may result in an inordinate influence of habits or environmental cues on behavior. A series of studies are proposed that will investigate the functional consequences of compromised cognitive control. The guiding hypothesis is that the anterior cingulate, a structure involved in monitoring one's behavior, is a core neurobiological deficit in cocaine users. As this structure is thought to initiate the involvement of other prefrontal structures central to implementing cognitive control, we propose that these prefrontal """"""""deficits"""""""" may be secondary to the cingulate deficit. A further major aim of the proposed research is to assess the persistence or amelioration of cognitive dysfunctions following drug abstinence. The proposed research will assess the executive neurofunctioning of cocaine users at the start and end of a one-year period of abstinence. Tasks will include measures of inhibitory control, error detection, adaptive control (i.e., behavioral flexibility) and attentional control (i.e., being able to ignore cocaine stimuli). The research will also assess if dysfunction in these processes is predictive of relapse or ameliorates with abstinence. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA014100-07
Application #
7430474
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Grant, Steven J
Project Start
2001-09-30
Project End
2010-05-31
Budget Start
2008-06-01
Budget End
2010-05-31
Support Year
7
Fiscal Year
2008
Total Cost
$265,497
Indirect Cost
Name
Nathan Kline Institute for Psychiatric Research
Department
Type
DUNS #
167204762
City
Orangeburg
State
NY
Country
United States
Zip Code
10962
Kong, Xiang-Zhen; Mathias, Samuel R; Guadalupe, Tulio et al. (2018) Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A 115:E5154-E5163
Bell, Ryan P; Foxe, John J; Ross, Lars A et al. (2014) Intact inhibitory control processes in abstinent drug abusers (I): a functional neuroimaging study in former cocaine addicts. Neuropharmacology 82:143-50
Morie, Kristen P; Garavan, Hugh; Bell, Ryan P et al. (2014) Intact inhibitory control processes in abstinent drug abusers (II): a high-density electrical mapping study in former cocaine and heroin addicts. Neuropharmacology 82:151-60
Garavan, H; Brennan, K L; Hester, R et al. (2013) The neurobiology of successful abstinence. Curr Opin Neurobiol 23:668-74
Hester, Robert; Bell, Ryan P; Foxe, John J et al. (2013) The influence of monetary punishment on cognitive control in abstinent cocaine-users. Drug Alcohol Depend 133:86-93
Connolly, Colm G; Bell, Ryan P; Foxe, John J et al. (2013) Dissociated grey matter changes with prolonged addiction and extended abstinence in cocaine users. PLoS One 8:e59645
Connolly, Colm G; Foxe, John J; Nierenberg, Jay et al. (2012) The neurobiology of cognitive control in successful cocaine abstinence. Drug Alcohol Depend 121:45-53
Bell, Ryan P; Foxe, John J; Nierenberg, Jay et al. (2011) Assessing white matter integrity as a function of abstinence duration in former cocaine-dependent individuals. Drug Alcohol Depend 114:159-68
Simões-Franklin, Cristina; Hester, Robert; Shpaner, Marina et al. (2010) Executive function and error detection: The effect of motivation on cingulate and ventral striatum activity. Hum Brain Mapp 31:458-69
Roberts, Gloria M P; Nestor, Liam; Garavan, Hugh (2009) Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task. Brain Res 1292:71-81

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