: Surveillance data from the field's best monitoring systems are detecting alarming increases in the rates of """"""""club drug use"""""""" among young adults; yet, we know little about club drug abuse and dependence. Such information is essential to a relevant public health response. The proposed """"""""Tri-City Study"""""""" will be the first study of the applicability, reliability and validity of abuse and dependence concepts as they apply to specific """"""""club drugs."""""""" Specifically, a multisite study is proposed among 450 recent Ecstasy and other club drug users, 15 to 30 years of age, in areas indicated by NIDA's Community Epidemiology Workgroup (CEWG) as emerging or current areas of high risk -- St. Louis, Seattle and Miami -- to: 1) Describe the nature and extent of self-reported dependence on and abuse of Ecstasy, GHB, rohypnol and ketamine. This will be accomplished by determining whether """"""""cookie cutter"""""""" diagnostic criteria used for other illicit drugs (such as described in DSM-IV, III-R, III, and ICD-10 and the Edwards-Gross Dependence Syndrome) are generalizable to individual club drugs, and to what extent users report the hallmark symptoms of dependence and abuse such as tolerance, withdrawal, craving, loss of control and social consequences; 2) a) Expand the Substance Abuse Module (SAM) to assess abuse of and dependence on specific club drugs and b) determine the psychometric properties (reliability and validity) of these disorders; 3) Understand the reasons for inconsistent answers and misunderstood questions; 4) Develop and test a Risk Behavior Assessment to facilitate the collection of risk factor data relevant to club drug use, abuse and dependence; 5) Conduct qualitative research on the unique contextual factors that relate to club drug use, in each site, to help inform revisions to the SAM and the RBA; 6) Disseminate the aggregate findings to the drug abuse field. Such efforts, considered mundane to many in the drug abuse field, are critical at this early stage of the club drug epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA014854-03
Application #
6642229
Study Section
Special Emphasis Panel (ZDA1-WXG-F (07))
Program Officer
Obrien, Moira
Project Start
2001-09-30
Project End
2005-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
3
Fiscal Year
2003
Total Cost
$450,694
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Ramtekkar, Ujjwal P; Striley, Catherine W; Cottler, Linda B (2011) Contextual profiles of young adult ecstasy users: A multisite study. Addict Behav 36:190-6
Leung, Kit Sang; Ben Abdallah, Arbi; Copeland, Jan et al. (2010) Modifiable risk factors of ecstasy use: risk perception, current dependence, perceived control, and depression. Addict Behav 35:201-8
Shacham, Enbal; Cottler, Linda B (2010) Sexual behaviors among club drug users: prevalence and reliability. Arch Sex Behav 39:1331-41
Cottler, Linda B; Leung, Kit Sang; Abdallah, Arbi Ben (2009) Test-re-test reliability of DSM-IV adopted criteria for 3,4-methylenedioxymethamphetamine (MDMA) abuse and dependence: a cross-national study. Addiction 104:1679-90
Mennes, Catharine E; Ben Abdallah, Arbi; Cottler, Linda B (2009) The reliability of self-reported cannabis abuse, dependence and withdrawal symptoms: multisite study of differences between general population and treatment groups. Addict Behav 34:223-6
Scheier, Lawrence M; Ben Abdallah, Arbi; Inciardi, James A et al. (2008) Tri-city study of Ecstasy use problems: a latent class analysis. Drug Alcohol Depend 98:249-63
Inciardi, James A; Surratt, Hilary L; Kurtz, Steven P et al. (2007) Mechanisms of prescription drug diversion among drug-involved club- and street-based populations. Pain Med 8:171-83
Abdallah, Arbi Ben; Scheier, Lawrence M; Inciardi, James A et al. (2007) A psycho-economic model of ecstasy consumption and related consequences: a multi-site study with community samples. Subst Use Misuse 42:1651-84
Cottler, Linda B; Grant, Bridget F (2006) Characteristics of nosologically informative data sets that address key diagnostic issues facing the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V) and International Classification of Diseases, eleventh edition (ICD-11) subst Addiction 101 Suppl 1:161-9
Cottler, Linda B; Campbell, Wilbur; Krishna, V A S et al. (2005) Predictors of high rates of suicidal ideation among drug users. J Nerv Ment Dis 193:431-7

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