Adolescence is a time of vulnerability for youth where depression rates increase, particularly in girls, and smoking behaviors are also initiated. Increased morbidity and mortality in women who are smokers has been highlighted by recent statistics showing that women now have an increased rate of smoking over the last several decades. Morbidity and mortality is usually defined by cardiovascular and respiratory disorders. Less attention has been paid to the effect of smoking on aspects of health such as the relationship between smoking and depression and anxiety, and in turn, their combined effects on reproductive and bone health. No studies have examined such issues in puberty.
The aims of this study are to examine: (1) baseline relationships between puberty, smoking status, depression anxiety, reproductive and bone health, (2) causal direction between smoking status and depression and anxiety across 3 years, (3) characteristics of individual differences in developmental trajectories of: (a) reproductive and (b) bone health (accrual of bone mineral content; BMC) across a 3 year period, (4) the systematic effects of timing of puberty, smoking status and depression and anxiety on individual differences in developmental trajectories of reproductive and bone health (accrual of BMC) across a 3 year period, (5) the relationship of individual differences in developmental trajectories of adolescent reproductive health with individual differences in developmental trajectories of bone health across a 3 year period, and (6) whether baseline levels of smoking status, depression, and pubertal timing predict the simultaneous developmental trajectories of reproductive and bone health. The study will include 252 girls, ages 11-17 years enrolled in a cross-sequential design for three annual visits. Measures include smoking status, depression and anxiety, pubertal timing, gonadal and adrenal hormones, menstrual cycle information, and accrual of BMC. Examining the combined impact of smoking, depression and anxiety, on timing of puberty has import for future intervention and prevention strategies. Any negative influence during this critical period, such as smoking or depression, may have significant long-term consequences for bone (i.e. increased risk of osteoporotic fracture) or reproductive health (i.e. menstrual irregularity & endocrine disruption, infertility, dysmenorrhea). ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
7R01DA016402-02
Application #
6837281
Study Section
Special Emphasis Panel (ZRG1-BBBP-3 (02))
Program Officer
Khalsa, Jagjitsingh H
Project Start
2004-02-01
Project End
2009-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
2
Fiscal Year
2003
Total Cost
$536,610
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Beal, Sarah J; Dorn, Lorah D; Berga, Sarah L (2018) Examining the Validity of Self-reported Primary and Secondary Exposure to Cigarette Smoke in Adolescent Girls: The Utility of Salivary Cotinine as a Biomarker. Subst Use Misuse 53:792-799
Dorn, Lorah D; Gayles, Jochebed G; Engeland, Christopher G et al. (2016) Cytokine Patterns in Healthy Adolescent Girls: Heterogeneity Captured by Variable and Person-Centered Statistical Strategies. Psychosom Med 78:646-56
Beal, Sarah J; Grimm, Kevin J; Dorn, Lorah D et al. (2016) Morningness-Eveningness and Physical Activity in Adolescent Girls: Menarche as a Transition Point. Child Dev 87:1106-14
Beal, Sarah J; Hillman, Jennifer; Dorn, Lorah D et al. (2015) Associations between the prenatal environment and cardiovascular risk factors in adolescent girls: Internalizing and externalizing behavior symptoms as mediators. Child Health Care 44:17-39
Beal, Sarah J; Dorn, Lorah D; Sucharew, Heidi J et al. (2014) Characterizing the longitudinal relations between depressive and menstrual symptoms in adolescent girls. Psychosom Med 76:547-54
Beal, Sarah J; Negriff, Sonya; Dorn, Lorah D et al. (2014) Longitudinal associations between smoking and depressive symptoms among adolescent girls. Prev Sci 15:506-15
Riis, Jenna L; Out, Dorothee; Dorn, Lorah D et al. (2014) Salivary cytokines in healthy adolescent girls: Intercorrelations, stability, and associations with serum cytokines, age, and pubertal stage. Dev Psychobiol 56:797-811
Dorn, Lorah D; Beal, Sarah J; Kalkwarf, Heidi J et al. (2013) Longitudinal impact of substance use and depressive symptoms on bone accrual among girls aged 11-19 years. J Adolesc Health 52:393-9
Dorn, Lorah D; Sontag-Padilla, Lisa M; Pabst, Stephanie et al. (2013) Longitudinal reliability of self-reported age at menarche in adolescent girls: variability across time and setting. Dev Psychol 49:1187-93
Hillman, Jennifer B; Dorn, Lorah D; Loucks, Tammy L et al. (2012) Obesity and the hypothalamic-pituitary-adrenal axis in adolescent girls. Metabolism 61:341-8

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