American Indian (AI) reservation populations face numerous chronic stressors. Poverty, unemployment, violence, and accidents are all common, and it has been argued that the combination of historical trauma, inconsistent and disruptive governmental policies, and mandated boarding schools, have rendered many in current reservation populations especially vulnerable to both the impact of everyday chronic stressors, to substance misuse, and to PTSD. Drug use has also been documented among AIs, with AI youth often reporting greater use of drugs and tobacco than many others in the U.S. Only recently have data about the prevalence of drug disorders become available; such data suggest drug disorder rates that are comparable to other populations, but with age trends reflecting that AI youth are at increased risk for lifetime use of both drugs and tobacco compared to their elders suggesting an upward trend in drug disorders among AIs. Thus, the focus of the proposed research on the relationship between chronic stressors and drug use and disorders in this population is particularly timely. The data from the American Indian Service Utilization, Psychiatric Epidemiology; Risk and Protective Factors Project (AI-SUPERPFP) provide a unique opportunity for an epidemiological investigation of stress and drug disorders in an understudied population with a comprehensive assessment of chronic stressors (historical traumas, family history, childhood stressors, traumatic events, chronic strains, frequent lifetime events, and macro level stressors) in combination with standard measures of use and disorder for 9 drugs. The following specific aims guide this work: 1) To characterize and estimate the epidemiology of chronic stressors in these 2 reservation populations; 2) To understand and describe the relationships between chronic stressors, drug use, and DSM-defined drug abuse and dependence in these populations; 3) To investigate and portray the relationships between chronic stressors, drug use and disorders, and co-occurring problems including PTSD, other DSM-defined problems (depressive, anxiety, and alcohol disorders), and violence and antisocial behavior. Within each specific aim, the role of important demographic correlates (e.g., gender, tribe, SES, and age) and personal resources (coping, self-esteem, external locus of control, social support, spirituality, ethnic identity, and treatment history) will be investigated. The American Indian and Alaska Native Programs (AIANP) provide a distinctive multidisciplinary environment in which to conduct this work. The proposed work promises to provide the most comprehensive and focused investigation to date of chronic stressors within Al populations and of the relationship of various stressors with drug use and disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA017803-03
Application #
7064847
Study Section
Special Emphasis Panel (ZDA1-KXN-G (05))
Program Officer
Etz, Kathleen
Project Start
2004-05-01
Project End
2008-04-30
Budget Start
2006-05-01
Budget End
2008-04-30
Support Year
3
Fiscal Year
2006
Total Cost
$375,953
Indirect Cost
Name
University of Colorado Denver
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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Whitesell, Nancy Rumbaugh; Beals, Janette; Mitchell, Christina M et al. (2009) Childhood exposure to adversity and risk of substance-use disorder in two American Indian populations: the meditational role of early substance-use initiation. J Stud Alcohol Drugs 70:971-81
Whitesell, Nancy Rumbaugh; Mitchell, Christina M; Spicer, Paul (2009) A longitudinal study of self-esteem, cultural identity, and academic success among American Indian adolescents. Cultur Divers Ethnic Minor Psychol 15:38-50
Jiang, Luohua; Beals, Janette; Whitesell, Nancy R et al. (2008) Stress burden and diabetes in two American Indian reservation communities. Diabetes Care 31:427-9
Whitesell, Nancy Rumbaugh; Beals, Janette; Mitchell, Christina M et al. (2007) Marijuana initiation in 2 American Indian reservation communities: comparison with a national sample. Am J Public Health 97:1311-8
Whitesell, Nancy Rumbaugh; Beals, Janette; Mitchell, Christina M et al. (2007) The relationship of cumulative and proximal adversity to onset of substance dependence symptoms in two American Indian communities. Drug Alcohol Depend 91:279-88
Whitesell, Nancy Rumbaugh; Beals, Janette; Mitchell, Christina M et al. (2007) Disparities in drug use and disorder: comparison of two American Indian reservation communities and a national sample. Am J Orthopsychiatry 77:131-41
Manson, Spero M; Beals, Janette; Klein, Suzell A et al. (2005) Social epidemiology of trauma among 2 American Indian reservation populations. Am J Public Health 95:851-9