four pa.qes) ..................... 12 Other Biographical Sketches (Not to exceed four pages for each - See instructions)) ............................ 15 Resources ........................................................................................................................................................ 42 Research Plan Introduction to Revised Application (Notto exceed 3 pages) ................................................................................................................ Introduction to Supplemental Application (Not to exceed one page) ..................................................................................................... 48 A.
Specific Aims .. .......................................................................... ._. ......................................................................................... 48 B. Background and Significance ................................................... .....|. ........................................................................................ I 57 C, Preliminary Studies/Progress Report/ _ (Items A-D: not to exceed 25 pages*) """"""""_t Phase I Progress Report (SBIR/STTR Phase II ONLY) F SBIR/STTR Phase l: ltems A-D limited t?15 pages I [3. Research Design and Methods ................................................ _ .......................................................................................... 62 E. Human Subjects .......................................................................................................................................................................... 73 Protection of Human Subjects (Required if Item 4 on the Face Page is marked """"""""Yes"""""""") Inclusion of Women (Required if Item 4 on the Face Page is marked """"""""Yes"""""""") ...................................................................... Inclusion of Minorities (Required if Item 4 on the Face Page is marked """"""""Yes"""""""") .................................................................... Inclusion of Children (Required if Item 4 on the Face Page is marked """"""""Yes"""""""") ...................................................................... Data and Safety Monitoring Plan (Required if Item 4 on the Face Page is marked """"""""Yes"""""""" anda Phase I, II, or III clinical trial is proposed ............................................................................................................................................................... F. Vertebrate Animals ...................................................................................................................................................................... G. Literature Cited ............................................................................................................................................................................ 82 H. Consortium/Contractual Arrangements ....................................................................................................................................... I. Letters of Support (e.g., Consultants) ......................................................................................................................................... 96 J. Product Development Plan (SBIRISTTR Phase II and Fast-Track ONLY) ............................................................................... Checklist ........................................................................................................................................................... 102 Check if Appendix (Five collated sets. No page numbering necessary for Appendix.) Appendix is Included Appendices NO T PERMITTED for Phase I SBIR/S TTR unless specifically solicited. Number of publications and manuscdpts accepted for publication (not to exceed 10) Other items (list): Appendix I Color Plates of Figures in Preliminary Studies PHS 398 (Rev. 05/01) Page 3 Form Page 3

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
3R01DA017959-04S1
Application #
7466339
Study Section
Special Emphasis Panel (ZDA1-KXN-G (05))
Program Officer
Grant, Steven J
Project Start
2004-06-01
Project End
2009-05-31
Budget Start
2007-06-01
Budget End
2009-05-31
Support Year
4
Fiscal Year
2007
Total Cost
$94,878
Indirect Cost
Name
Mclean Hospital
Department
Type
DUNS #
046514535
City
Belmont
State
MA
Country
United States
Zip Code
02478
Elman, Igor; Gurvits, Tamara V; Tschibelu, Evelyne et al. (2013) Neurological soft signs in individuals with pathological gambling. PLoS One 8:e60885
Elman, Igor; Becerra, Lino; Tschibelu, Evelyne et al. (2012) Yohimbine-induced amygdala activation in pathological gamblers: a pilot study. PLoS One 7:e31118
Moulton, Eric A; Elman, Igor; Pendse, Gautam et al. (2011) Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images. J Neurosci 31:3795-804
Elman, Igor; Zubieta, Jon-Kar; Borsook, David (2011) The missing p in psychiatric training: why it is important to teach pain to psychiatrists. Arch Gen Psychiatry 68:12-20
Elman, Igor; Tschibelu, Evelyne; Borsook, David (2010) Psychosocial stress and its relationship to gambling urges in individuals with pathological gambling. Am J Addict 19:332-9
Elman, Igor; Lowen, Steven; Frederick, Blaise B et al. (2009) Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder. Biol Psychiatry 66:1083-90
Yamamoto, Rinah; Ariely, Dan; Chi, Won et al. (2009) Gender differences in the motivational processing of babies are determined by their facial attractiveness. PLoS One 4:e6042
Hopper, James W; Pitman, Roger K; Su, Zhaohui et al. (2008) Probing reward function in posttraumatic stress disorder: expectancy and satisfaction with monetary gains and losses. J Psychiatr Res 42:802-7
Rott, D; Langleben, D D; Elman, I (2008) Cocaine decreases plasma insulin concentrations in non-diabetic subjects: a randomized double-blind study. Diabet Med 25:510-1
Elman, Igor; Chi, Won H; Gurvits, Tamara V et al. (2008) Impaired reproduction of three-dimensional objects by cocaine-dependent subjects. J Neuropsychiatry Clin Neurosci 20:478-84

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