Despite the widespread use of cannabis, there has been relatively little research exploring patterns and correlates of use, abuse and dependence within genetically informative research designs. This study will supplement existing data from two ongoing studies of male (DA 12540, PI Madden) and female (AA 09022 PI Heath) twins by collecting comprehensive information on patterns of cannabis use, escalation in use and related harm from the twins' full siblings aged 18-30 (projected n =1,600). Combining data from these three sources will ensure adequate statistical power to address the following issues:
AIM 1 : To determine at what stages in the progression of cannabis use heritable influences first arise, by assessing the timing and onset of stages in the development of cannabis use disorders including: first exposure/opportunity to use; experimentation, escalating use, quantity used, the experience of first abuse/ dependence symptom and the onset of abuse or dependence.
AIM 2 : To assess subjective reactions to cannabis, the extent to which such responses are influenced by heritable factors, the extent to which such reactions may be correlated with risks for the development of cannabis use disorders and the extent of overlap in the genetic and environmental influences associated with subjective reactions to cannabis and those associated with liability to cannabis use disorders.
AIM 3 : To examine patterns of comorbid psychopathology (including other substance use/ dependence) associated with cannabis use/dependence and the extent to which qualitatively distinct heritable subtypes of cannabis use/dependence can be identified on the basis of comorbid psychopathology.
AIM 4 : To assess the psychometric properties of an assessment of cannabis use disorders (abuse, dependence) within the context of a genetically informative research design, and examine the genetic covariance structure of individual symptoms of abuse/dependence.
AIM 5 : Based on these analyses, to formulate a model for unfolding of genetic influences on transitions in cannabis and the emergence of dependence symptoms.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA018660-03
Application #
7092111
Study Section
Special Emphasis Panel (ZDA1-EXL-T (01))
Program Officer
Weinberg, Naimah Z
Project Start
2004-09-30
Project End
2009-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
3
Fiscal Year
2006
Total Cost
$648,336
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Maciejewski, Dominique F; Renteria, Miguel E; Abdellaoui, Abdel et al. (2017) The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries. Behav Genet 47:3-10
Power, R A; Verweij, K J H; Zuhair, M et al. (2014) Genetic predisposition to schizophrenia associated with increased use of cannabis. Mol Psychiatry 19:1201-4
Agrawal, Arpana; Lynskey, Michael T (2014) Have the genetics of cannabis involvement gone to pot? Nebr Symp Motiv 61:71-108
Maciejewski, Dominique F; Creemers, Hanneke E; Lynskey, Michael T et al. (2014) Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology? JAMA Psychiatry 71:699-705
Agrawal, Arpana; Madden, Pamela A F; Bucholz, Kathleen K et al. (2014) Initial reactions to tobacco and cannabis smoking: a twin study. Addiction 109:663-71
Verweij, K J H; Agrawal, A; Nat, N O et al. (2013) A genetic perspective on the proposed inclusion of cannabis withdrawal in DSM-5. Psychol Med 43:1713-22
Verweij, Karin J H; Huizink, Anja C; Agrawal, Arpana et al. (2013) Is the relationship between early-onset cannabis use and educational attainment causal or due to common liability? Drug Alcohol Depend 133:580-6
Agrawal, A; Verweij, K J H; Gillespie, N A et al. (2012) The genetics of addiction-a translational perspective. Transl Psychiatry 2:e140
Scherrer, Jeffrey F; Grant, Julia D; Agrawal, Arpana et al. (2012) Suicidal behavior, smoking, and familial vulnerability. Nicotine Tob Res 14:415-24
Grant, Julia D; Scherrer, Jeffrey F; Lynskey, Michael T et al. (2012) Associations of alcohol, nicotine, cannabis, and drug use/dependence with educational attainment: evidence from cotwin-control analyses. Alcohol Clin Exp Res 36:1412-20

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