? ? The proposed Stage I-B study focuses on adolescents who meet criteria for both Borderline Personality Disorder (BPD) and Substance Abuse Disorder. These adolescents display a pattern of self-destructive behaviors (suicide attempts, self-mutilization, violent reactions) that intensify and exacerbate their drug abuse, and severely disrupt treatment and family relations. This constellation of symptoms and their severity require specialized interventions. A previous NIDA funded Stage I study led to the development of the Integrative Borderline Adolescent Family Therapy (I-BAFT) model that integrated 1) Linehan's work on skills training specifically for Borderline adults with 2) family treatment based on Structural Family Therapy shown efficacious with substance abusing adolescents and 3) individual level interventions adapted for this specific subtype of drug abuser. This application proposes to conduct a """"""""Stage I-B study of behavioral and psychosocial therapies for substance abuse disorder"""""""" testing the newly developed I-BAFT in a small randomized trial and providing a more substantial test of its efficacy, to obtain the necessary indicators needed for a Stage II trial. In addition to focusing on drug and BPD outcomes, the study will also obtain preliminary indicators of impact on hypothesized mediators (e .g. family functioning and emotion regulation). We will recruit 40 drug-abusing adolescents (20 male and 20 female, 14-17 years of age) who meet DSM-IV criteria for BPD, and their families. Participants will be recruited from the Juvenile Addictions Receiving Facility (JARF) at the University of Miami/Jackson Memorial Hospital and the Juvenile Assessment Center (JAC). The adolescents and their families will be randomly assigned to either the (1) I-BAFT condition, or (2) the Individual Drug Counseling (IDC) condition. Both treatment conditions are manualized and have adherence checklists available. Both I-BAFT and IDC will be implemented as seven-month interventions with two sessions per week. Assessments will be conducted at baseline, mid-treatment (4 months), post-treatment (8 months), and follow-up (12 months). Longitudinal data analysis (growth curve modeling) and Clinical Significance v/ill be used to test study hypotheses. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA019057-04
Application #
7491751
Study Section
Special Emphasis Panel (ZDA1-RXL-E (06))
Program Officer
Subramaniam, Geetha A
Project Start
2005-08-16
Project End
2010-07-31
Budget Start
2008-08-01
Budget End
2010-07-31
Support Year
4
Fiscal Year
2008
Total Cost
$441,616
Indirect Cost
Name
University of Miami School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Santisteban, Daniel A; Mena, Maite P; Muir, Joan et al. (2015) The efficacy of two adolescent substance abuse treatments and the impact of comorbid depression: results of a small randomized controlled trial. Psychiatr Rehabil J 38:55-64
Santisteban, Daniel A; Coatsworth, J Douglas; Briones, Ervin et al. (2012) Beyond acculturation: an investigation of the relationship of familism and parenting to behavior problems in Hispanic youth. Fam Process 51:470-82
Santisteban, Daniel A; Mena, Maite P; McCabe, Brian E (2011) Preliminary results for an adaptive family treatment for drug abuse in Hispanic youth. J Fam Psychol 25:610-4
Santisteban, Daniel A; Mena, Maite P (2009) Culturally informed and flexible family-based treatment for adolescents: a tailored and integrative treatment for Hispanic youth. Fam Process 48:253-68
Mena, Maite P; Mitrani, Victoria B; Muir, Joan A et al. (2008) Extended parent-child separations: impact on substance-abusing Hispanic adolescents. J Spec Pediatr Nurs 13:50-2