This revised R01 application requests support to study a significant and growing but understudied drug use problem, non-medical prescription analgesic use (NMPAU). We seek to shed new light on gender differences in the epidemiology of NMPAU and associated problems for both adolescents and adults. We propose to conduct secondary analyses of data from 2002-2005 National Surveys on Drug Use and Health (NSDUH). There are four specific aims.
The first aim i s to examine gender differences in the incidence and determinants of first NMPAU, including incidence trends, risk periods for initiation, and determinants of recent initiation.
The second aim i s to determine gender differences in the patterns, sequences, and correlates of multidrug use among non-medical prescription analgesic users (NMPAUs), including injection drug use, multidrug use, and the developmental sequence from first NMPAU to other drug use (eg, cocaine, heroin, and other prescription drugs).
The third aim i s to examine gender differences in the prevalence and correlates of NMPAU disorders and the other substance use disorders, including recent trends of NMPAU disorders.
The fourth aim i s to investigate gender differences in the utilization of substance abuse treatment services and of the perceived need for substance abuse treatment among NMPAUs, including the location of treatment services received, the primary abused substance for which treatment was received, the primary abused substance with perceived need for treatment, and barriers to treatment service utilization. These proposed analyses will add new findings to the literature regarding gender differences in the incidence, prevalence, and correlates of NMPAU and associated problems (sequence of multidrug use, injection drug use, abuse and dependence, patterns of service utilization, and barriers to service utilization). They will have important implications for early identification of NMPAUs, designs of prevention and treatment initiatives, estimates of treatment needs, and generating hypotheses for future research. Subgroups of NMPAUs with an increased likelihood of injection drug use, multidrug use, or drug dependence, and underserved NMPAUs will be identified for early prevention or be targeted to improve their access to substance abuse treatment services. Such findings will be vital to policy makers in predicting the potential burden of NMPAU-related problems. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA019901-02
Application #
7499531
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Obrien, Moira
Project Start
2007-09-20
Project End
2010-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
2
Fiscal Year
2008
Total Cost
$137,592
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Wu, Li-Tzy; Zhu, He; Mannelli, Paolo et al. (2017) Prevalence and correlates of treatment utilization among adults with cannabis use disorder in the United States. Drug Alcohol Depend 177:153-162
Wu, Li-Tzy; Brady, Kathleen T; Spratt, Susan E et al. (2016) Using electronic health record data for substance use Screening, Brief Intervention, and Referral to Treatment among adults with type 2 diabetes: Design of a National Drug Abuse Treatment Clinical Trials Network study. Contemp Clin Trials 46:30-38
Chen, Danhong; Wu, Li-Tzy (2016) Association Between Substance Use and Gun-Related Behaviors. Epidemiol Rev 38:46-61
Wu, Li-Tzy; Zhu, He; Swartz, Marvin S (2016) Treatment utilization among persons with opioid use disorder in the United States. Drug Alcohol Depend 169:117-127
Zhu, He; Wu, Li-Tzy (2016) Trends and Correlates of Cannabis-involved Emergency Department Visits: 2004 to 2011. J Addict Med 10:429-436
Chapman, Shawna L Carroll; Wu, Li-Tzy (2015) Associations between cigarette smoking and pain among veterans. Epidemiol Rev 37:86-102
Wu, L-T; Blazer, D G (2015) Substance use disorders and co-morbidities among Asian Americans and Native Hawaiians/Pacific Islanders. Psychol Med 45:481-94
Wu, Li-Tzy; Swartz, Marvin S; Brady, Kathleen T et al. (2015) Perceived cannabis use norms and cannabis use among adolescents in the United States. J Psychiatr Res 64:79-87
Wu, Li-Tzy; Brady, Kathleen T; Mannelli, Paolo et al. (2014) Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study. J Psychiatr Res 50:26-35
Fu, Qiang; Vaughn, Michael G; Wu, Li-Tzy et al. (2014) Psychiatric correlates of snuff and chewing tobacco use. PLoS One 9:e113196

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