We aim to study the neural mechanisms of behavioral treatment of cocaine dependence. Although multiple behavioral treatments including cognitive behavioral therapy (CBT) and contingency management (CM) have been shown to be effective in the treatment of cocaine dependence and other addictive disorders, little is known regarding the brain changes underlying their mechanisms of action. We propose integrating functional magnetic resonance imaging (fMRI) measures into a NIDA-funded behavioral treatment trial of CBT and CM to investigate brain function before and after treatment. We propose using at study onset and following 12 weeks of treatment three imaging paradigms that assess cocaine craving, reward processing and cognitive control, respectively. We propose using similar measures in a non-addicted control grouped imaged twice twelve weeks apart as an important comparison group. We predict that prior to treatment, cocaine dependent subjects will differ from controls on these fMRI and cognitive measures. We also predict that cocaine dependent subjects will show changes in fMRI and cognitive/behavioral functioning following treatment, and that control subjects will not show similar changes when imaged 12 weeks apart. Neural predictors and correlates of effective behavioral treatment for cocaine dependence for CBT and CM will be explored as these would have significant potential for refining therapies, and targeting specific therapies to specific forms of cocaine dependence (e.g., those with specific neural activation patterns). Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA020908-01
Application #
7046475
Study Section
Special Emphasis Panel (ZDA1-MXS-M (21))
Program Officer
Nemeth-Coslett, Rosemarie V
Project Start
2005-09-29
Project End
2010-07-31
Budget Start
2005-09-29
Budget End
2006-07-31
Support Year
1
Fiscal Year
2005
Total Cost
$380,327
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Yip, Sarah W; Worhunsky, Patrick D; Xu, Jiansong et al. (2018) Gray-matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions. Addict Biol 23:394-402
DeVito, Elise E; Dong, Guangheng; Kober, Hedy et al. (2017) Functional neural changes following behavioral therapies and disulfiram for cocaine dependence. Psychol Addict Behav 31:534-547
Yip, Sarah W; Morie, Kristen P; Xu, Jiansong et al. (2017) Shared microstructural features of behavioral and substance addictions revealed in areas of crossing fibers. Biol Psychiatry Cogn Neurosci Neuroimaging 2:188-195
Ren, Yudan; Fang, Jun; Lv, Jinglei et al. (2017) Assessing the effects of cocaine dependence and pathological gambling using group-wise sparse representation of natural stimulus FMRI data. Brain Imaging Behav 11:1179-1191
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Balodis, Iris M; Kober, Hedy; Worhunsky, Patrick D et al. (2016) Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. Neuropsychopharmacology 41:2112-21
Cui, Changhai; Noronha, Antonio; Warren, Kenneth R et al. (2015) Brain pathways to recovery from alcohol dependence. Alcohol 49:435-52
Xu, Jiansong; Calhoun, Vince D; Worhunsky, Patrick D et al. (2015) Functional network overlap as revealed by fMRI using sICA and its potential relationships with functional heterogeneity, balanced excitation and inhibition, and sparseness of neuron activity. PLoS One 10:e0117029
Xu, Jiansong; Calhoun, Vince D; Potenza, Marc N (2015) The absence of task-related increases in BOLD signal does not equate to absence of task-related brain activation. J Neurosci Methods 240:125-7
Mei, Songli; Xu, Jiansong; Carroll, Kathleen M et al. (2015) Self-reported impulsivity is negatively correlated with amygdalar volumes in cocaine dependence. Psychiatry Res 233:212-7

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