The prevalence of substance use is disproportionately high among Hispanic youth in the U.S., and substance use is increasing in Latin America. Yet substance use in Hispanic populations is vastly understudied. The relatively few studies with Hispanics consist mainly of cross-sectional samples or very short longitudinal designs (e.g., 2-3 years). They tend to rely on samples of school-attending youth and do not include information on biological insults that might impact later substance use. The proposed project addresses many of these limitations. It builds on an extraordinary sample of over 1,200 young Chilean adolescents and their families, who have been followed longitudinally since infancy. The sample was originally enrolled in conjunction with a NIH-supported study of the behavioral and developmental effects of preventing iron deficiency anemia in infancy. Comprehensive information on biological, individual, familial, and environmental factors was obtained in infancy and at 5 and 10 years. The children will be 11-15 years at the start of the proposed project, an age period when initiation of substance use, especially alcohol and tobacco, is exceptionally high in Chile. We propose to identify developmental pathways of substance use, abuse, and dependence in early to late adolescence. In the proposed five-year study we plan to conduct two comprehensive assessments of all adolescent-mother dyads, approximately two years apart. Guided by a life-course approach, we propose to investigate 3 Specific Aims:
Aim 1) To longitudinally characterize individual, familial, and environmental factors from infancy through adolescence that increase or decrease drug involvement in adolescence;
Aim 2) To identify cognitive, behavioral, and social consequences of substance use through an at-risk period and beyond;
and Aim 3) To determine the effects of a probable insult to the dopamine system in infancy (iron deficiency) on substance use and abuse in adolescence. Findings from the proposed study can contribute to our understanding of the etiology and prevention of substance use and abuse in two important ways: 1) To further the identification of pathways of drug involvement among Hispanic youth;and 2) To study developmental pathways of substance use within a multiple domain context that ranges from the biological to the environmental over a 15-year period.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA021181-05
Application #
8053446
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Obrien, Moira
Project Start
2007-04-23
Project End
2013-03-31
Budget Start
2011-04-01
Budget End
2013-03-31
Support Year
5
Fiscal Year
2011
Total Cost
$498,699
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Social Work
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Wu, Victoria; East, Patricia; Delker, Erin et al. (2018) Associations Among Mothers' Depression, Emotional and Learning-Material Support to Their Child, and Children's Cognitive Functioning: A 16-Year Longitudinal Study. Child Dev :
Doom, Jenalee R; Richards, Blair; Caballero, Gabriela et al. (2018) Infant Iron Deficiency and Iron Supplementation Predict Adolescent Internalizing, Externalizing, and Social Problems. J Pediatr 195:199-205.e2
East, Patricia; Delker, Erin; Lozoff, Betsy et al. (2018) Associations Among Infant Iron Deficiency, Childhood Emotion and Attention Regulation, and Adolescent Problem Behaviors. Child Dev 89:593-608
Elmore, Kristen; Delva, Jorge; Andrade, Fernando (2017) Gender differences in psychological factors shaping smoking decisions of Chilean adolescents. J Health Psychol 22:1721-1730
East, Patricia; Lozoff, Betsy; Blanco, Estela et al. (2017) Infant iron deficiency, child affect, and maternal unresponsiveness: Testing the long-term effects of functional isolation. Dev Psychol 53:2233-2244
Ma, Julie; Grogan-Kaylor, Andrew; Delva, Jorge (2016) Behavior Problems Among Adolescents Exposed to Family and Community Violence in Chile. Fam Relat 65:502-516
Delva, Jorge; Adaniya, Fernando Andrade; Sanhueza, Guillermo et al. (2015) Associations of maternal and adolescent religiosity and spirituality with adolescent alcohol use in Chile: Implications for social work practice among Chilean social workers. Int Soc Work 58:249-260
Han, Yoonsun; Grogan-Kaylor, Andrew; Delva, Jorge et al. (2014) Estimating the heterogeneous relationship between peer drinking and youth alcohol consumption in Chile using propensity score stratification. Int J Environ Res Public Health 11:11879-97
Martinez, Suzanna M; Blanco, Estela; Delva, Jorge et al. (2014) Perception of neighborhood crime and drugs increases cardiometabolic risk in Chilean adolescents. J Adolesc Health 54:718-23
Delva, Jorge; Lee, Wonhyung; Sanchez, Ninive et al. (2014) Ecological factors and adolescent marijuana use: results of a prospective study in Santiago, Chile. Int J Environ Res Public Health 11:3443-52

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