Abstract

The proposed work will explore mediated integration of data resources in the neuroscience community. The propossed mediator system, the Query Integrator Server, (QIS) is intended to faciliate interoperation between such resources by leveraging various semantic data models developed by other neuroinformatics researchers, in addition to using technologies derived from version-control and ontology research. Proof of concept will be obtained by close collaboration with two groups that are associated with the Human Brain Project: Biomedical Informatics Research Network (BIRN)-affiliated investigators from the University of California, San Diego, who are also working in the field of query mediation for federated databases, and the Gardner group at Cornell University, which is working on common semantic data models for neuroscience.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA021253-03
Application #
7356421
Study Section
Special Emphasis Panel (ZRG1-MDCN-K (55))
Program Officer
Aigner, Thomas G
Project Start
2006-04-01
Project End
2011-01-31
Budget Start
2008-03-10
Budget End
2011-01-31
Support Year
3
Fiscal Year
2008
Total Cost
$311,852
Indirect Cost

  Institution

Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Marenco, Luis N; Wang, Rixin; Bandrowski, Anita E et al. (2014) Extending the NIF DISCO framework to automate complex workflow: coordinating the harvest and integration of data from diverse neuroscience information resources. Front Neuroinform 8:58
Marenco, Luis N; Bahl, Gautam; Hyland, Lorra et al. (2013) Databases in SenseLab for the genomics, proteomics, and function of olfactory receptors. Methods Mol Biol 1003:3-22
Holford, Matthew E; Khurana, Ekta; Cheung, Kei-Hoi et al. (2010) Using semantic web rules to reason on an ontology of pseudogenes. Bioinformatics 26:i71-8
Marenco, Luis; Wang, Rixin; Shepherd, Gordon M et al. (2010) The NIF DISCO Framework: facilitating automated integration of neuroscience content on the web. Neuroinformatics 8:101-12
Nadkarni, Prakash M; Marenco, Luis A (2010) Implementing description-logic rules for SNOMED-CT attributes through a table-driven approach. J Am Med Inform Assoc 17:182-4
Samwald, Matthias; Lim, Ernest; Masiar, Peter et al. (2009) Entrez Neuron RDFa: a pragmatic semantic web application for data integration in neuroscience research. Stud Health Technol Inform 150:317-21
Marenco, Luis; Wang, Rixin; Nadkarni, Prakash (2009) Automated database mediation using ontological metadata mappings. J Am Med Inform Assoc 16:723-37
Cheung, Kei-Hoi; Lim, Ernest; Samwald, Matthias et al. (2009) Approaches to neuroscience data integration. Brief Bioinform 10:345-53
Marenco, Luis; Ascoli, Giorgio A; Martone, Maryann E et al. (2008) The NIF LinkOut broker: a web resource to facilitate federated data integration using NCBI identifiers. Neuroinformatics 6:219-27
Marenco, Luis; Li, Yuli; Martone, Maryann E et al. (2008) Issues in the design of a pilot concept-based query interface for the neuroinformatics information framework. Neuroinformatics 6:229-39

Showing the most recent 10 out of 12 publications