HIV-1 Infection is associated with adverse outcomes in endocrine systems. Illicit drug abuse is a major risk factor for contracting HIV-1 infection and is also associated with abnormal endocrine outcomes. Several studies including ours have reported exacerbated endocrine abnormalities among drug abusing HIV-1+ individuals. But these investigations have been carried out among cocaine and/or opioids addicts, and the culture of drug abuse in the United States is changing. Methamphetamine (meth) is becoming a drug of choice all over the country and its abuse in South Florida particularly among MSM has skyrocketed. There is, however, a scarcity of investigations on the impact of methamphetamine on endocrines in HIV-1 infection. It is hypothesized that adrenal activity will be increased, there will be a hyper activity of thyroid as well as an increased incidence of insulin resistance, among HIV-1+ meth abusing MSM. In order to test these hypotheses, this 5 year application proposes to investigate cross sectionally adrenal, thyroid, and insulin activity in a total of 450 men in three groups: HIV-1+ meth abusers (n=150), HIV-1- meth abusers (n=150), HIV-1 - non-meth abusers (n=150) distributed among African Americans, Caucasians, and Hispanics. Because of the planned focus on MSM, only men will be included in the study. The following are aims:
Aim 1 : To investigate adrenal activity (ACTH and cortisol levels) as well as response to the combined dexamethasone-CRH challenge among meth abusing-HIV-1+ MSM, meth abusing HIV-1- MSM and HIV-1- meth-free control participants.
Aim 2 : To investigate thyroid activity (TSH, T4 and T3) as well as thyroid antibodies among meth abusing-HIV-1+ MSM, meth abusing HIV-1- MSM and HIV-1- meth-free control participants.
Aim 3 : To explore insulin activity among meth abusing-HIV-1+ MSM;meth abusing HIV-1- MSM and HIV-1- meth-free control participants. These endocrine disturbances may lead to enormous burden of a number of serious medical consequences and outcomes in meth abusing MSM and further allow developing suitable interventions.
Methamphetamine (meth) abuse particularly among MSM in South Florida has skyrocketed. Although endocrine outcomes in HIV-1 infection as well as drug abusers with HIV- 1 infection have been investigated, there is scarcity of information regarding such outcomes in HIV-1+ meth abusing MSM. This proposal investigates adrenal, thyroid and insulin activities in this population. It is proposed that adverse endocrine outcomes may result in an enormous medical burden.
|Jones, Deborah L; Carrico, Adam W; Babayigit, Suat et al. (2018) Methamphetamine-associated dysregulation of the hypothalamic-pituitary-thyroid axis. J Behav Med 41:792-797|
|Carrico, Adam W; Rodriguez, Violeta J; Jones, Deborah L et al. (2018) Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV-positive, methamphetamine-using men who have sex with men. Hum Psychopharmacol 33:|
|Syed, Shariful A; Nemeroff, Charles B (2017) Early Life Stress, Mood, and Anxiety Disorders. Chronic Stress (Thousand Oaks) 1:|
|Nemeroff, Charles B (2016) Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect. Neuron 89:892-909|
|Lopez-Patton, Maria; Kumar, Mahendra; Jones, Deborah et al. (2016) Childhood trauma and METH abuse among men who have sex with men: Implications for intervention. J Psychiatr Res 72:1-5|
|Joshi, Hemant P; Subramanian, Indira V; Schnettler, Erica K et al. (2014) Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. Proc Natl Acad Sci U S A 111:5331-6|
|Nemeroff, Charles B (2013) Psychoneuroimmunoendocrinology: the biological basis of mind-body physiology and pathophysiology. Depress Anxiety 30:285-7|
|Nemeroff, Charles B; Goldschmidt-Clermont, Pascal J (2012) Heartache and heartbreak--the link between depression and cardiovascular disease. Nat Rev Cardiol 9:526-39|
|Myers, Amanda J; Nemeroff, Charles B (2012) APOE: a risk factor for multiple disorders. Am J Geriatr Psychiatry 20:545-8|
|Chittiprol, Seetharamaiah; Kumar, Adarsh M; Shetty, K Taranath et al. (2009) HIV-1 clade C infection and progressive disruption in the relationship between cortisol, DHEAS and CD4 cell numbers: a two-year follow-up study. Clin Chim Acta 409:4-10|