Despite the recent attention to high rates of mental health problems including substance use disorders among the US veterans of the wars in Iraq and Afghanistan, most of the reports have been focused on excessive alcohol use and related problems. While clinicians are confronted with increasing reports of heavy and problematic marijuana use among the veterans, research on this drug and its association with affective disorders (e.g., post-traumatic stress disorder and major depressive disorder) is virtually nonexistent. There is a paucity of studies on the natural course of marijuana use and associated problems and there are no prospective studies on the comorbidity of cannabis use and affective disorders among veterans following deployment. The goal of this application is to conduct the first comprehensive prospective investigation of the trajectories of marijuana use, related problems, cannabis use disorders and concomitant affective disorders among 400 Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) veterans recruited from the Veterans Administration Medical Center post-deployment. The proposed longitudinal design is a particular strength in examining theoretically-determined predictors of change in marijuana use trajectories. Change (escalation and de-escalation over one year) and stability in marijuana use and abuse, alcohol, and other drug use disorders will be examined using latent transition analysis, and longitudinal associations will be examined using latent growth curve modeling. The proposed study will identify putative mechanisms (using marijuana for coping reasons) and investigate the moderating effects of individual differences (emotional vulnerability, cognitive, psychosocial, and physical/medical factors) that may explicate the relationship between negative affect (DSM-IV mood or anxiety disorder and/or state negative affectivity) and marijuana use/disorders. Using stratified sampling with proportional allocation, an equal proportion of frequent weekly marijuana users, past month users, infrequent past year users and non-users with lifetime history of marijuana use will be selected to allow for heterogeneity in examining longitudinal patterns of change in marijuana use. This study has the potential to yield information about the mechanisms that underlie the development of co morbidity and addictive disorders, a clinical problem that has substantial impact on public health due to increasing costs of addiction-related and mental health disability. Findings from this study will have wide-ranging implications for the assessment and treatment of OEF/OIF/OND veterans with co-occurring substance use and affective disorders and ultimately for providing them with a higher quality of life.

Public Health Relevance

Many people use marijuana to cope with depression and anxiety, which leads to more severe psychiatric symptoms and worse outcomes with respect to marijuana-related problems and marijuana use disorders. Marijuana use along with co-occurring mental health problems like post-traumatic stress disorder and depression are of particular concern among the US veterans of the wars in Iraq and Afghanistan who are returning home from the war. This research will help identify individuals who are particularly vulnerable to developing comorbid substance use and affective disorders and will track changes in veterans'marijuana and other drug use over one year with the goal of ultimately improving detection and treatment of substance use disorders.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
Project #
Application #
Study Section
Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Schulden, Jeffrey D
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brown University
Public Health & Prev Medicine
Schools of Public Health
United States
Zip Code
Gunn, Rachel L; Jackson, Kristina M; Borsari, Brian et al. (2018) Negative urgency partially accounts for the relationship between major depressive disorder and marijuana problems. Borderline Personal Disord Emot Dysregul 5:10
Orchowski, Lindsay M; Berry-Cabán, Cristóbal S; Prisock, Kara et al. (2018) Evaluations of Sexual Assault Prevention Programs in Military Settings: A Synthesis of the Research Literature. Mil Med 183:421-428
Metrik, Jane; Gunn, Rachel L; Jackson, Kristina M et al. (2018) Daily Patterns of Marijuana and Alcohol Co-Use Among Individuals with Alcohol and Cannabis Use Disorders. Alcohol Clin Exp Res 42:1096-1104
Borsari, Brian; Yalch, Matthew M; Pedrelli, Paola et al. (2018) Associations among trauma, depression, and alcohol use profiles and treatment motivation and engagement in college students. J Am Coll Health :1-11
Metrik, Jane; Bassett, Shayna S; Aston, Elizabeth R et al. (2018) Medicinal versus Recreational Cannabis Use among Returning Veterans. Transl Issues Psychol Sci 4:6-20
Kazemi, Donna M; Borsari, Brian; Levine, Maureen J et al. (2017) A Systematic Review of the mHealth Interventions to Prevent Alcohol and Substance Abuse. J Health Commun 22:413-432
Kazemi, Donna M; Borsari, Brian; Levine, Maureen J et al. (2017) Systematic review of surveillance by social media platforms for illicit drug use. J Public Health (Oxf) 39:763-776
Miller, Mary Beth; Van Reen, Eliza; Barker, David H et al. (2017) The impact of sleep and psychiatric symptoms on alcohol consequences among young adults. Addict Behav 66:138-144
Yurasek, Ali M; Merrill, Jennifer E; Metrik, Jane et al. (2017) Marijuana use in the context of alcohol interventions for mandated college students. J Subst Abuse Treat 79:53-60
Primack, Jennifer M; Borsari, Brian; Benz, Madeline B et al. (2017) Mental health treatment utilization in OIF/OEF National Guard and Reserve troops with and without DSM diagnoses. Am J Orthopsychiatry 87:157-165

Showing the most recent 10 out of 13 publications