The impacts that drug addictions have on health disparities that adversely affect African Americans are grossly understudied. While there is strong evidence linking drug abuse to poor health and problem behaviors in the African American community, the progression of drug abuse is inconsistent (i.e., relatively late initiation and heavy use in the 30s) with national norms and remains unclear. Exposure to chronic stress and the subsequent activation of the hypothalamic-pituitary-adrenal (HPA) axis has been connected to drug addictions and poor health outcomes. This association is of particular importance since residents in these communities are exposed to many of the risk factors associated with the onset of drug abuse: familial risk, deprived social environment, unemployment, substandard education, low-to-no socioeconomic status, and enduring exposure to experiences of racism and discrimination. Repeated exposure to environmental stressors will lead to 'wear-and-tear'on the body's regulatory system and have profound implications on HPA functioning and the subsequent risk of developing an addiction. This study will pursue three primary aims: (1) Investigate HPA reactivity to acute stress as a predictor of current drug use severity. (2) Investigate trajectories of HPA regulation (level and circadian rhythm) as a predicto of drug use vulnerability across time. (3) Investigate delay discounting as a moderator between trajectories of HPA regulation and drug use vulnerability across time. This study will enroll 350 African American adults (ages 18-21) who reside in the southeastern U.S. and utilize a prospective longitudinal research design that consists of a laboratory assessment involving the Trier Social Stress Test, three in-home assessments that include clinical interviews and behavioral tasks, and six internet assessments that track drug use and related risk factors across a 2-year period. Primary independent variables include environmental stressors, stress-related biomarkers (i.e., salivary cortical, salivary DHEA, heart rate variability, and galvanic skn resistance), and delay discounting. Primary dependent variables include drug use, severity of drug use disorders, and drug use consequences. This study is highly innovative for three primary reasons: (1) A longitudinal research design will be used for the first time to investigate trajectories of HPA regulation as a predictor of drug use vulnerability;(2) The use of multiple indicators of the stress regulatory system, clinical interviews, and a novel behavioral task provides a more nuanced understanding of the research aims;and (3) This study focuses on an understudied population that suffers from drug-related health disparities, but are rarely included in cutting edge laboratory research. It is envisioned that this approach will uncover latent-curve trajectories of stress deregulation as a predictor of drug use vulnerability in this population. Findings from this study will identify causal mechanisms of drug addictions that will advance theory, research, prevention, and treatments aimed at addressing this growing public health problem.

Public Health Relevance

The development of drug abuse in the African American community is often characterized by oversimplified models that are rooted in research studies that rarely include African Americans. This study will identify mechanisms that influence drug use vulnerability in at-risk African American adults who reside in the southeastern U.S. Such research is needed to develop socially and culturally informed prevention and treatment programs aimed at reducing drug-related health disparities that continue to plague African Americans.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-RPIA-N (09))
Program Officer
Schulden, Jeffrey D
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Houston
Schools of Education
United States
Zip Code
Steers, Mai-Ly N; Chen, Tzu-An; Neisler, Julie et al. (2018) The buffering effect of social support on the relationship between discrimination and psychological distress among church-going African-American adults. Behav Res Ther :
Reitzel, Lorraine R; Smith, Nathan Grant; Obasi, Ezemenari M et al. (2017) Perceived distress tolerance accounts for the covariance between discrimination experiences and anxiety symptoms among sexual minority adults. J Anxiety Disord 48:22-27
Pittman, Delishia M; Brooks, Jessica J; Kaur, Paramjit et al. (2017) The cost of minority stress: Risky alcohol use and coping-motivated drinking behavior in African American college students. J Ethn Subst Abuse :1-22
Shirtcliff, Elizabeth A; Skinner, Martie L; Obasi, Ezemenari M et al. (2017) Positive parenting predicts cortisol functioning six years later in young adults. Dev Sci 20:
Reitzel, Lorraine R; Childress, Sarah D; Obasi, Ezemenari M et al. (2017) Interactive Effects of Anxiety Sensitivity and Subjective Social Status on Psychological Symptomatology in Black Adults. Behav Med 43:268-276
Pittman, Delishia M; Cho Kim, Sara; Hunter, Carla D et al. (2017) The role of minority stress in second-generation Black emerging adult college students' high-risk drinking behaviors. Cultur Divers Ethnic Minor Psychol 23:445-455
Obasi, Ezemenari M; Shirtcliff, Elizabeth A; Cavanagh, Lucia et al. (2017) Hypothalamic-Pituitary-Adrenal Reactivity to Acute Stress: an Investigation into the Roles of Perceived Stress and Family Resources. Prev Sci 18:923-931
Obasi, Ezemenari M; Brooks, Jessica J; Cavanagh, Lucia (2016) The Relationship Between Psychological Distress, Negative Cognitions, and Expectancies on Problem Drinking: Exploring a Growing Problem Among University Students. Behav Modif 40:51-69
Obasi, Ezemenari M; Cavanagh, Lucia; Pittman, Delishia M et al. (2016) Effects of Evaluative Context in Implicit Cognitions Associated with Alcohol and Violent Behaviors. Addict Behav Rep 3:48-55
Reitzel, Lorraine R; Okamoto, Hiroe; Hernandez, Daphne C et al. (2016) The Built Food Environment and Dietary Intake among African-American Adults. Am J Health Behav 40:3-11

Showing the most recent 10 out of 12 publications